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Heparan Sulfate

Name: Heparan Sulfate
Brand: TargetMol
SKU: T19355
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19355Cas No. 9050-30-0

Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.

Heparan Sulfate

🥰Excellent

Catalog No. T19355Cas No. 9050-30-0

Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$97	In Stock
10 mg	$163	In Stock
25 mg	$322	In Stock
50 mg	$538	In Stock
100 mg	$777	In Stock

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Product Introduction

Bioactivity

Description	Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.
Targets&IC50	RBD:0.02 μg/mL, MCF-10A cells (AR-induced mitogenesis):2 μg/mL
In vitro	METHODS: Breast cancer cells MDA-MB231 were treated with Heparan sulfate (20 µg/mL) for 24 h and detected by Fluorescence microscopy. RESULTS: Cell spreading was enhanced and the average spreading cell area approximately doubled in the presence of Heparan sulfate. Exogenous Heparan sulfate blocked cell invasion and matrix degradation. [1]
In vivo	METHODS: To assay anti-tumor activity in vivo, Heparan sulfate (0.8 mg/kg) was administered to SCID-hu mice injected with bone marrow aspirates from myeloma patients twice daily, once intraperitoneally and once subcutaneously, for four weeks. RESULTS: Treatment with Heparan sulfate significantly inhibited primary tumor growth in a human severe combined immunodeficiency (SCID-hu) myeloma model. [2]

Chemical Properties

Molecular Weight	593.47(monomer)
Formula	C₁₂H₁₉NO₂₀S₃ (monomer)
Cas No.	9050-30-0
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Insoluble

H2O: 100 mg/mL (168.50 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	NaN mL	NaN mL	NaN mL	NaN mL
5 mM	NaN mL	NaN mL	NaN mL	NaN mL
10 mM	NaN mL	NaN mL	NaN mL	NaN mL
20 mM	NaN mL	NaN mL	NaN mL	NaN mL
50 mM	NaN mL	NaN mL	NaN mL	NaN mL
100 mM	NaN mL	NaN mL	NaN mL	NaN mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc