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Heparan Sulfate

🥰Excellent
Catalog No. T19355Cas No. 9050-30-0

Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.

Heparan Sulfate

Heparan Sulfate

🥰Excellent
Catalog No. T19355Cas No. 9050-30-0
Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$44In StockIn Stock
5 mg$97In StockIn Stock
10 mg$163In StockIn Stock
25 mg$322In StockIn Stock
50 mg$538In StockIn Stock
100 mg$777In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG) that is tightly attached to cell surface or extracellular matrix proteins.
Targets&IC50
RBD:0.02 μg/mL, MCF-10A cells (AR-induced mitogenesis):2 μg/mL
In vitro
METHODS: Breast cancer cells MDA-MB231 were treated with Heparan sulfate (20 µg/mL) for 24 h and detected by Fluorescence microscopy.
RESULTS: Cell spreading was enhanced and the average spreading cell area approximately doubled in the presence of Heparan sulfate. Exogenous Heparan sulfate blocked cell invasion and matrix degradation. [1]
In vivo
METHODS: To assay anti-tumor activity in vivo, Heparan sulfate (0.8 mg/kg) was administered to SCID-hu mice injected with bone marrow aspirates from myeloma patients twice daily, once intraperitoneally and once subcutaneously, for four weeks.
RESULTS: Treatment with Heparan sulfate significantly inhibited primary tumor growth in a human severe combined immunodeficiency (SCID-hu) myeloma model. [2]
Chemical Properties
Molecular Weight593.47(monomer)
FormulaC12H19NO20S3 (monomer)
Cas No.9050-30-0
Smiles[N].CO[C@@H]1OC(COS(O)(=O)=O)[C@H](O[C@@H]2OC([C@H](O[C@@H]3OC(COS(O)(=O)=O)[C@H](O[C@@H]4OC([C@H](OC)[C@H](O)[C@@H]4OS(O)(=O)=O)C(O)=O)[C@H](O)[C@@H]3NS(O)(=O)=O)[C@H](O)[C@@H]2O)C(O)=O)[C@H](OS(O)(=O)=O)[C@@H]1NS(O)(=O)=OjcExt:v:0:0
Relative Density.no data available
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: Insoluble
H2O: 100 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

βcateninWnt/β-cateninWnt/betacateninWnt/b-cateninWntInhibitorinhibitHuman Endogenous MetaboliteHeparan SulfateHeparanFibroblast growth factor receptorFGFREndogenousMetaboliteEndogenous Metabolitebeta-cateninbetacateninbcatenin
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