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Naftidrofuryl oxalate

Name: Naftidrofuryl oxalate
Brand: TargetMol
SKU: T1081
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1081Cas No. 3200-06-4

Alias Nafronyl oxalate salt, Nafronyl oxalate

Naftidrofuryl oxalate (Nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It may also be an antagonist at 5HT-2 serotonin receptors.

Naftidrofuryl oxalate

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Purity: 98.38%

Catalog No. T1081Alias Nafronyl oxalate salt, Nafronyl oxalateCas No. 3200-06-4

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	-
500 mg	$53	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.38%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Naftidrofuryl oxalate AI Summary

Naftidrofuryl oxalate exhibits a range of bioactivities, including enzyme inhibition and receptor antagonism. It shows potency as an inhibitor targeting various enzymes and interactions, including human Jumonji Domain Containing 2E, Menin-MLL Interaction, Fructose-1,6-bisphosphate Aldolase, Cytochrome P450 3A4 (both inhibitory and activator activity), JMJD2A-Tudor Domain, BAZ2B, HP1-beta Chromodomain, Polymerase Iota, Regulator of G Protein Signaling 4, tyrosyl-DNA phosphodiesterase 1 (TDP1), and exhibits antiviral activity against Lassa, Marburg, and Ebola Viruses. Additionally, the compound binds to Mycobacterium tuberculosis pantothenate synthetase, affecting its alpha-helix and beta-sheet structures, with an inhibitory concentration (IC50) value of 398390.0 nM. It also functions as a serotonin 2A (5HT2A) receptor antagonist with Ki values of 256.45 nM and 331.13 nM. Furthermore, it inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells by 74.24% and 116.47% respectively at a 10 µM concentration. In assays related to SARS-CoV-2 (strain BavPat1) in Vero E6 cells, Naftidrofuryl oxalate exhibits a moderate cell viability inhibition index of 0.8036..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Naftidrofuryl oxalate (Nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It may also be an antagonist at 5HT-2 serotonin receptors.
Synonyms	Nafronyl oxalate salt, Nafronyl oxalate

Chemical Properties

Molecular Weight	473.56
Formula	C₂₆H₃₅NO₇
Cas No.	3200-06-4
Smiles	OC(=O)C(O)=O.CCN(CC)CCOC(=O)C(CC1CCCO1)Cc1cccc2ccccc12
Relative Density.	1.2205 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.58 mM), Sonication is recommended.

H2O: 198.5 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1117 mL	10.5583 mL	21.1166 mL	105.5832 mL
5 mM	0.4223 mL	2.1117 mL	4.2233 mL	21.1166 mL
10 mM	0.2112 mL	1.0558 mL	2.1117 mL	10.5583 mL
20 mM	0.1056 mL	0.5279 mL	1.0558 mL	5.2792 mL
50 mM	0.0422 mL	0.2112 mL	0.4223 mL	2.1117 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc