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STC-15

Name: STC-15
Brand: TargetMol
SKU: T78210
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78210Cas No. 2648257-56-9

Alias STC15

STC-15 is an orally active and potent METTL3 inhibitor with anticancer activity that inhibits cancer growth and induces anticancer immunity.

STC-15

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Purity: 99.71%

Catalog No. T78210Alias STC15Cas No. 2648257-56-9

STC-15 is an orally active and potent METTL3 inhibitor with anticancer activity that inhibits cancer growth and induces anticancer immunity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$162	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$397	In Stock	In Stock
50 mg	$619	In Stock	In Stock
100 mg	$786	-	In Stock
1 mL x 10 mM (in DMSO)	$177	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.71%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

STC-15 AI Summary

STC-15 demonstrates inhibitory activity against the protein METTL3 in a methyltransferase assay with an IC50 of 6.1 nM. Additionally, it shows antiproliferative effects on Kasumi 1 cells with an IC50 of 586.7 nM and on Caov-3 cells with an IC50 of 237.1 nM after 120 hours, as measured by Cell Titer Glo assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	STC-15 is an orally active and potent METTL3 inhibitor with anticancer activity that inhibits cancer growth and induces anticancer immunity.
Synonyms	STC15

Chemical Properties

Molecular Weight	415.49
Formula	C₂₄H₂₅N₅O₂
Cas No.	2648257-56-9
Smiles	O=C1C=C(N=C2C=CC=CN12)C(=O)NCC=3C=CC=4C=C(NC4C3)CNCC5CCC5

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (240.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4068 mL	12.0340 mL	24.0680 mL	120.3398 mL
5 mM	0.4814 mL	2.4068 mL	4.8136 mL	24.0680 mL
10 mM	0.2407 mL	1.2034 mL	2.4068 mL	12.0340 mL
20 mM	0.1203 mL	0.6017 mL	1.2034 mL	6.0170 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4068 mL
100 mM	0.0241 mL	0.1203 mL	0.2407 mL	1.2034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc