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Izencitinib

Name: Izencitinib
Brand: TargetMol
SKU: T35898
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35898Cas No. 2051918-33-1

Alias TD-1473, JNJ-8398

Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.

Izencitinib

🥰Excellent

Purity: 99.82%

Catalog No. T35898Alias TD-1473, JNJ-8398Cas No. 2051918-33-1

Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.

Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$197	In Stock
10 mg	$313	In Stock
25 mg	$629	In Stock
50 mg	$987	In Stock
100 mg	$1,590	In Stock
200 mg	$2,180	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.82%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Izencitinib (JNJ-8398) is an orally active and gut-selective JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.
Targets&IC50	JAK3:9.5(pKi), JAK1:10.0(pKi), JAK2:8.8 (pKi)
In vitro	Izencitinib ( TD-1473 ), as an effective inhibitor of JAK1, JAK2 and JAK3, can act on the human JAK kinase domain ( pKi values are 10.0,8.8 and 9.5, respectively )[1].
In vivo	Izencitinib ( TD-1473,1 mg / kg BID ) can be used in oxazolone-induced colitis in mice[1].
Synonyms	TD-1473, JNJ-8398

Chemical Properties

Molecular Weight	402.50
Formula	C₂₂H₂₆N₈
Cas No.	2051918-33-1
Smiles	Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4CCC#N)n2)n[nH]1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (74.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4845 mL	12.4224 mL	24.8447 mL	124.2236 mL
5 mM	0.4969 mL	2.4845 mL	4.9689 mL	24.8447 mL
10 mM	0.2484 mL	1.2422 mL	2.4845 mL	12.4224 mL
20 mM	0.1242 mL	0.6211 mL	1.2422 mL	6.2112 mL
50 mM	0.0497 mL	0.2484 mL	0.4969 mL	2.4845 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc