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H-1152 dihydrochloride

Name: H-1152 dihydrochloride
Brand: TargetMol
SKU: T35328
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T35328Cas No. 871543-07-6

Alias H-1152 dihydrochloride, H-1152 2HCl

H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

H-1152 dihydrochloride

🥰Excellent

Purity: 99.85%

Catalog No. T35328Alias H-1152 dihydrochloride, H-1152 2HClCas No. 871543-07-6

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$145	In Stock
10 mg	$239	In Stock
25 mg	$462	In Stock
50 mg	$728	In Stock
100 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.85%

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COA HNMR LCMS IC

Product Introduction

Bioactivity

Description	H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Targets&IC50	PKG (cell-free assay):0.360 μM, Abl:7.77 μM, MLCK:28.3 μM, CaMK II (cell-free assay):0.180 μM, PKC:5.68 μM, MKK4:16.9 μM, p38α:100 μM, EGFR:50 μM, GSK-3α:60.7 μM, PKA (cell-free assay):3.03 μM, Src:3.06 μM, ROCK2 (cell-free assay):0.0120 μM, AMPK:100 μM, Aurora A (cell-free assay):0.745 μM
In vitro	H-1152 dihydrochloride shows less inhibitory activities against Src, MLCK, Abl, EGFR, MKK4, GSK3α, AMPK, and P38α, with IC50s of 3.06, 28.3, 7.77, 50.0, 16.9, 60.7, 100, and 100 μM, respectively[1]. H-1152 dihydrochloride slightly suppresses PKA, PKC and MLCK, with Kis of 0.63, 9.27, and 10.1 μM, respectively. In LPA-treated cells, H-1152 dihydrochloride (0.1-10 µM) inhibits MARCKS phosphorylation (IC50 = 2.5 µM)[2]. H-1152 dihydrochloride (0.5-10 μM) does not decrease neuronal survival or alter the ratios of different neuronal morphologies. H-1152 dihydrochloride (10 μM) arguments neurite length in both BMP4 and LIF cultures[3].
Synonyms	H-1152 dihydrochloride, H-1152 2HCl

Chemical Properties

Molecular Weight	392.34
Formula	C₁₆H₂₃Cl₂N₃O₂S
Cas No.	871543-07-6
Smiles	Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (101.95 mM), Sonication is recommended.

H2O: 32.1 mg/mL (81.9 mM ), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5488 mL	12.7440 mL	25.4881 mL	127.4405 mL
5 mM	0.5098 mL	2.5488 mL	5.0976 mL	25.4881 mL
10 mM	0.2549 mL	1.2744 mL	2.5488 mL	12.7440 mL
20 mM	0.1274 mL	0.6372 mL	1.2744 mL	6.3720 mL
50 mM	0.0510 mL	0.2549 mL	0.5098 mL	2.5488 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0255 mL	0.1274 mL	0.2549 mL	1.2744 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc