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LY2510924

Name: LY2510924
Brand: TargetMol
SKU: T15805
Rating: 4.5 (1 reviews)

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Catalog No. T15805Cas No. 1088715-84-7

LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).

LY2510924

😃Good

Catalog No. T15805Cas No. 1088715-84-7

LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$797	7-10 days	7-10 days
50 mg	$1,280	7-10 days	7-10 days
100 mg	$1,940	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).
Targets&IC50	SDF-1α-CXCR4:49.5 pM (ki), SDF-1α-CXCR4:79.7 pM
In vitro	LY2510924 inhibits SDF-1–induced cell migration (IC50: 0.26 nM) and inhibits SDF-1/CXCR4-mediated intracellular signaling, in human lymphoma U937 cells expressing endogenous CXCR4. LY2510924 also inhibits SDF-1–induced GTP binding (Kb: 0.38 nM). LY2510924 specifically blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM). LY2510924 displays a concentration-dependent inhibition of SDF-1–stimulated phospho-ERK and phospho-Akt in tumor cells. Biochemical and cellular analyses reveal that LY2510924 has no apparent agonist activity[1]. LY2510924 chiefly inhibits the proliferation of AML cells with little induction of cell death and reduces protection against chemotherapy by stromal cells[2].

Chemical Properties

Molecular Weight	1189.45
Formula	C₆₂H₈₈N₁₄O₁₀
Cas No.	1088715-84-7
Smiles	[H][C@]1(CCCNC(N)=N)NC(=O)[C@H](CCCCNC(C)C)NC(=O)[C@]([H])(Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CC[C@@H](NC(=O)CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O)C(=O)N[C@@H](CCCCNC(C)C)C(N)=O
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (105.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (2.77 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8407 mL	4.2036 mL	8.4072 mL	42.0362 mL
5 mM	0.1681 mL	0.8407 mL	1.6814 mL	8.4072 mL
10 mM	0.0841 mL	0.4204 mL	0.8407 mL	4.2036 mL
20 mM	0.0420 mL	0.2102 mL	0.4204 mL	2.1018 mL
50 mM	0.0168 mL	0.0841 mL	0.1681 mL	0.8407 mL
100 mM	0.0084 mL	0.0420 mL	0.0841 mL	0.4204 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc