Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antitumor agent-53 is a potent compound that effectively inhibits tumor growth. It achieves this by inducing cell cycle arrest at the G2/M phase and promoting apoptosis in HGC-27 cells through the inhibition of the PI3K/AKT pathway. Furthermore, Antitumor agent-53 holds promise for further research in the treatment of gastrointestinal tumors [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 2,140.00 | |
50 mg | 6-8 weeks | $ 2,785.00 | |
100 mg | 6-8 weeks | $ 3,520.00 |
Description | Antitumor agent-53 is a potent compound that effectively inhibits tumor growth. It achieves this by inducing cell cycle arrest at the G2/M phase and promoting apoptosis in HGC-27 cells through the inhibition of the PI3K/AKT pathway. Furthermore, Antitumor agent-53 holds promise for further research in the treatment of gastrointestinal tumors [1]. |
In vitro | Antitumor agent-53 (compound 6f) demonstrated dose-dependent anti-proliferative activity across various cell lines (HGC-27, HT-29, HepG-2, A549, MCF7, GES-1) with IC50 values ranging from 0.37 to >18 μM after 72 hours of treatment. Notably, it inhibited cell proliferation in HGC-27 and HT-29 cells at concentrations of 0.15, 0.3, and 0.6 μM. At 200 μM, it also displayed inhibitory effects on Topo I. The compound induced cell cycle arrest at the G2/M phase in HGC-27 and HT-29 cells with 0.1, 0.3, and 0.9 μM concentrations after 24 hours. Furthermore, it promoted apoptosis and inhibited cell migration and invasion in these cell lines in a concentration-dependent manner, with observed effects ranging from 0.1 to 2.7 μM over 24 hours. Antitumor agent-53 also suppressed the PI3K/AKT pathway, further inducing apoptosis in HGC-27 cells at 0.1, 0.3, and 0.9 μM, highlighting its potential as a multifaceted antitumor compound. |
Molecular Weight | 383.42 |
Formula | C24H18FN3O |
CAS No. | 2757145-67-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Antitumor agent-53 2757145-67-6 inhibitor inhibit