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CCR2 antagonist 4

Name: CCR2 antagonist 4
Brand: TargetMol
SKU: T13114
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13114Cas No. 226226-39-7

Alias Teijin compound 1

CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist with IC50 values of 180 nM and 24 nM for CCR2 inhibition and MCP-1-induced chemotaxis inhibition, respectively.

CCR2 antagonist 4

🥰Excellent

Purity: 99.86%

Catalog No. T13114Alias Teijin compound 1Cas No. 226226-39-7

CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist with IC50 values of 180 nM and 24 nM for CCR2 inhibition and MCP-1-induced chemotaxis inhibition, respectively.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$123	In Stock
10 mg	$198	In Stock
25 mg	$347	In Stock
50 mg	$515	In Stock
100 mg	$733	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock

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Purity:99.86%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist with IC50 values of 180 nM and 24 nM for CCR2 inhibition and MCP-1-induced chemotaxis inhibition, respectively.
Targets&IC50	CCR2b:180 nM
In vivo	Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta in ApoE-deficient mice[3].
Synonyms	Teijin compound 1

Chemical Properties

Molecular Weight	439.86
Formula	C₂₁H₂₁ClF₃N₃O₂
Cas No.	226226-39-7
Smiles	FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (113.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2735 mL	11.3673 mL	22.7345 mL	113.6725 mL
5 mM	0.4547 mL	2.2735 mL	4.5469 mL	22.7345 mL
10 mM	0.2273 mL	1.1367 mL	2.2735 mL	11.3673 mL
20 mM	0.1137 mL	0.5684 mL	1.1367 mL	5.6836 mL
50 mM	0.0455 mL	0.2273 mL	0.4547 mL	2.2735 mL
100 mM	0.0227 mL	0.1137 mL	0.2273 mL	1.1367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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