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[1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene](chloro)silver
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Catalog No. T212772Cas No. 873297-20-2
[1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene](chloro)silver is a silver-N-heterocyclic carbene (Silver-NHC) complex with potent anticancer activity. It effectively inhibits the proliferation of various cancer cell lines by inducing apoptosis. Distinct from classical pathways, its mechanism is independent of caspase activation. Instead, it triggers the release of mitochondrial Apoptosis-Inducing Factor (AIF), which translocates to the nucleus to cause chromatin condensation and large-scale DNA fragmentation. As a novel organometallic anticancer lead, SIPrAgCl holds significant promise for research aimed at overcoming conventional drug resistance in tumors.
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[1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene](chloro)silver
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Purity: 99.97%
Catalog No. T212772Cas No. 873297-20-2
[1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene](chloro)silver is a silver-N-heterocyclic carbene (Silver-NHC) complex with potent anticancer activity. It effectively inhibits the proliferation of various cancer cell lines by inducing apoptosis. Distinct from classical pathways, its mechanism is independent of caspase activation. Instead, it triggers the release of mitochondrial Apoptosis-Inducing Factor (AIF), which translocates to the nucleus to cause chromatin condensation and large-scale DNA fragmentation. As a novel organometallic anticancer lead, SIPrAgCl holds significant promise for research aimed at overcoming conventional drug resistance in tumors.
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Purity:99.97%
Appearance:Solid
Color:White
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| Description | [1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene](chloro)silver is a silver-N-heterocyclic carbene (Silver-NHC) complex with potent anticancer activity. It effectively inhibits the proliferation of various cancer cell lines by inducing apoptosis. Distinct from classical pathways, its mechanism is independent of caspase activation. Instead, it triggers the release of mitochondrial Apoptosis-Inducing Factor (AIF), which translocates to the nucleus to cause chromatin condensation and large-scale DNA fragmentation. As a novel organometallic anticancer lead, SIPrAgCl holds significant promise for research aimed at overcoming conventional drug resistance in tumors. |
| In vitro | The cytotoxicity of [1,3-Bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene](chloro)silver was evaluated in HCT116 and MCF-7 cell lines using MTT assays. Results demonstrated high anti-proliferative potency, with IC50 values in the low micromolar range. Apoptotic features were analyzed via flow cytometry and immunofluorescence. Results confirmed the loss of mitochondrial transmembrane potential and the translocation of AIF from the mitochondria to the nucleus. The cell death induction remained unaffected by caspase inhibitors, validating a caspase-independent apoptotic mechanism [1]. |
| Molecular Weight | 533.93 |
| Formula | C27H38AgClN2 |
| Cas No. | 873297-20-2 |
| Smiles | Cl[Ag]=C1N(C=2C(=CC=CC2C(C)C)C(C)C)CCN1C=3C(=CC=CC3C(C)C)C(C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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