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PI3K-IN-38

Name: PI3K-IN-38
Brand: TargetMol
SKU: T61618
Price: 82 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61618Cas No. 1382979-64-7

PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 µM for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activity and inhibits tumor growth in vivo.

PI3K-IN-38

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Purity: 99.89%

Catalog No. T61618Cas No. 1382979-64-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$82	-	In Stock
5 mg	$181	-	In Stock
10 mg	$267	-	In Stock
25 mg	$413	-	In Stock
50 mg	$571	-	In Stock
100 mg	$763	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 µM for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activity and inhibits tumor growth in vivo.
Targets&IC50	p110α:0.541 μM

Chemical Properties

Molecular Weight	380.44
Formula	C₂₀H₂₄N₆O₂
Cas No.	1382979-64-7
Smiles	CC1(C)C2=NC=3C(N2CCO1)=NC(=NC3N4CCOCC4)C5=CC=C(N)C=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (157.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6285 mL	13.1427 mL	26.2854 mL	131.4268 mL
5 mM	0.5257 mL	2.6285 mL	5.2571 mL	26.2854 mL
10 mM	0.2629 mL	1.3143 mL	2.6285 mL	13.1427 mL
20 mM	0.1314 mL	0.6571 mL	1.3143 mL	6.5713 mL
50 mM	0.0526 mL	0.2629 mL	0.5257 mL	2.6285 mL
100 mM	0.0263 mL	0.1314 mL	0.2629 mL	1.3143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc