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Malonic acid

Name: Malonic acid
Brand: TargetMol
SKU: T5291
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5291Cas No. 141-82-2

Alias Propanedioic Acid, Carboxyacetic Acid, 1,3-Propanedioic Acid

Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency, which is an inborn error of metabolism.

Malonic acid

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Purity: 99.53%

Catalog No. T5291Alias Propanedioic Acid, Carboxyacetic Acid, 1,3-Propanedioic AcidCas No. 141-82-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$46	In Stock	In Stock
50 mg	$66	In Stock	In Stock
100 mg	$96	In Stock	In Stock
500 mg	$138	In Stock	In Stock
1 g	$209	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.53%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Malonic acid (propanedioic acid) is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain. Malonic acid is found to be associated with malonyl-CoA decarboxylase deficiency, which is an inborn error of metabolism.
Synonyms	Propanedioic Acid, Carboxyacetic Acid, 1,3-Propanedioic Acid

Chemical Properties

Molecular Weight	104.06
Formula	C₃H₄O₄
Cas No.	141-82-2
Smiles	OC(=O)CC(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (2402.46 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.6098 mL	48.0492 mL	96.0984 mL	480.4920 mL
5 mM	1.9220 mL	9.6098 mL	19.2197 mL	96.0984 mL
10 mM	0.9610 mL	4.8049 mL	9.6098 mL	48.0492 mL
20 mM	0.4805 mL	2.4025 mL	4.8049 mL	24.0246 mL
50 mM	0.1922 mL	0.9610 mL	1.9220 mL	9.6098 mL
100 mM	0.0961 mL	0.4805 mL	0.9610 mL	4.8049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc