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Glucosidase

Glucosidase belongs to the glycoside hydrolase family of enzymes and plays a crucial role in breaking down glucosidic bonds to release glucose. Glucosidase is essential for sugar metabolism in organisms, found across a wide range of sources and present in almost all cellular structures that utilize carbohydrates for energy. This enzyme comes in two main types: β-glucosidase, involved in cellulose metabolism and various physiological pathways, and α-glucosidase, which directly participates in starch and glycogen metabolism. Dysfunctions in these enzymes can lead to metabolic disorders. Moreover, glucosidase serves as a target for various drugs and inhibitors aimed at regulating sugar metabolism in the human body.

Conduritol B epoxide
TQ03006090-95-5
Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).
  • $41
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Gcase activator 1
T42801919820-28-2
Gcase activator 1 (LTI-291) is a glucocerebrosidase (Gcase) activator.
  • $41
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Daucosterol
T3871474-58-8
Daucosterol (Sitogluside) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol(β-Sitosterol β-D-glucoside) has efficient and inexpensive neuroprotectant effect, to contribute to IGF1-like activity, could be potentially developed as a medicine for ischemic stroke treatment.
  • $41
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1-Deoxynojirimycin
T367519130-96-2
1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.
  • $38
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Bisabolone oxide A
T3979422567-38-0
Bisabolone oxide A is a terpenoid isolated from Matricaria chamomilla L. It reduces neuronal excitability.Bisabolone oxide A inhibits α glucokinase and has been shown to inhibit α glucokinase in Helicoverpa armigera, Aedes vittatus, and Anopheles subpictus larvae and showed biotoxicity in Helicoverpa armigera, Aedes vittatus and Anopheles subpictus larvae experiments.
  • $397
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Pinoresinol diglucoside
T6S053563902-38-5
1. Pinoresinol diglucoside (Pinoresinol Diglucopyranoside) is a putative α-glucosidase inhibiting compound. 2. Pinoresinol diglucoside is a important antihypertensive compound.
  • $45
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Acarbose
T024756180-94-0
Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.
  • $35
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Isovitexin
T6S137138953-85-4
1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.
  • $44
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ethyl rosmarinate
TN6784174591-47-0
ethyl rosmarinate inhibit the activity of tyrosinase, α-glucosidase, and matrix metalloproteinase-1 (MMP-1).
  • $64
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Mulberrofuran G
TN195687085-00-5
Mulberrofuran G, isolated from Morus alba L., has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death. Mulberrofuran G is a dual inhibitor of PTP1B and alpha-glucosidase for use in the study of Alzheimer's disease.
  • $222
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Brevifolincarboxylic acid
TN145118490-95-4
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM.
  • $77
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kuwanon G
T3S161275629-19-5
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has anti-inflammatory activity, it can attenuate atherosclerosis through inhibiting foam cell formation and inflammatory response. 3. Kuwanon G is a potent inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B. 4. Kuwanon G shows acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activities, it may be a promising candidate for preventive and therapeutic agents for Alzheimer's disease. 5. Kuwanon G prevents the pathological progression of allergic asthma through the inhibition of lung destruction by inflammation and immune stimulation. 6. Kuwanon G has antibacterial activity against oral pathogens. 7. Kuwanon G is a specific antagonist for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
  • $60
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Gcase activator 3
T864962270984-21-7
Gcase activator 3 is a glucocerebrosidase (GCase) activator, promoting increased GCase activity in GBA1 mutant fibroblasts. Gcase activator 3 is useful for studying Parkinson's disease.
  • $265
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Kaempferol-3,7-di-O-β-glucoside
TN436825615-14-9
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena that inhibits α-amylase, α-glucosidase, and acetylcholinesterase. It exhibits neuroprotective activity, slowing amyloid β peptide-induced damage in differentiated neuronal cells SH-SY5Y, and can be used in the study of neurological disorders such as Alzheimer's disease.
  • $176
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N-Caffeoyl O-methyltyramine
T12142189307-47-9
N-Caffeoyl O-methyltyramine is isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
  • $48
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Manghaslin
TN213055696-57-6
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibitory activity against AChE
  • $113
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Voglibose
T672383480-29-9
Voglibose (Glustat), an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia and various disorders caused by hyperglycemia.
  • $30
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Castanospermine
TQ030879831-76-8
Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
  • $32
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α-Glucosidase-IN-23
T67728161187-57-1In house
α-Glucosidase-IN-23 is an orally active inhibitor of α-glucosidase that can decrease blood glucose levels by inhibiting α-glucosidase (IC50 = 4.48 μM).
  • $118
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IHVR-17028
T388941428247-78-2In house
IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively. IHVR-17028 can be used to study infectious diseases.
  • $297
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Tryptophan, N-indol-3-ylacetyl- (6CI)
T548957105-53-0
Tryptophan, N-indol-3-ylacetyl- (6CI) (Indole-3-acetyl-L-tryptophan) is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may also be used in the synthesis of β-D-galactosidase and β-D-glucosidase inhibitors.
  • $30
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4',5-Dihydroxyflavone
T82606665-67-4
4',5-Dihydroxyflavone is a soybean LOX-1 inhibitor (Ki: 102.6 μM) and a yeast α-Glucosidase inhibitor (IC50: 66 μM).
  • $34
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Terphenyllin
T1313052452-60-5
Terphenyllin has α-glucosidase inhibitory activity, and is a natural product isolated from the coral derived fungus Aspergillus candidus.
  • $113
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Butyl isobutyl phthalate
T831917851-53-5
Butyl isobutyl phthalate (ButylIsobutylPhthalate) is a non-competitive α-glucosidase inhibitor(IC50 :38 μM),it shows a hypoglycemic effect
  • $31
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