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WNK-IN-11

🥰Excellent
Catalog No. T5456Cas No. 2123489-30-3
Alias Allosteric WNK Kinase Inhibitor

WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)

WNK-IN-11

WNK-IN-11

🥰Excellent
Purity: 98.32%
Catalog No. T5456Alias Allosteric WNK Kinase InhibitorCas No. 2123489-30-3
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$84In StockIn Stock
5 mg$190In StockIn Stock
10 mg$312In StockIn Stock
25 mg$526In StockIn Stock
50 mg$759In StockIn Stock
100 mg$1,070In StockIn Stock
500 mg$2,130-In Stock
1 mL x 10 mM (in DMSO)$209In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.32%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) is an allosteric With-No-Lysine (WNK) kinase inhibitor,WNK1(IC50 : 4 nM)
Targets&IC50
WNK1:4 nM
In vitro
WNK-IN-11 (compound 11) demonstrates potent activity with an IC50 value of less than 2 μM in the OSR1 phosphorylation assay, exhibits reasonable water solubility, and shows relatively high microsomal clearance. It functions through ATP noncompetitive inhibition. When tested against a comprehensive panel of 440 human kinases at 10 μM, 2500-fold higher than the enzyme's IC50, WNK-IN-11 exhibits high selectivity, with significant off-target inhibition only against BTK and the feline encephalitis virus-related (FER) kinase, neither of which are involved in blood pressure regulation. This specificity highlights its potential as a targeted therapeutic agent, likely due to its predicted allosteric binding outside the conserved ATP-pocket region.
SynonymsAllosteric WNK Kinase Inhibitor
Chemical Properties
Molecular Weight462.4
FormulaC21H21Cl2N5OS
Cas No.2123489-30-3
SmilesCNc1nc(cs1)-c1cc(C(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c(Cl)cn1
Relative Density.1.407 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Insoluble
DMSO: 150 mg/mL (324.39 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.65 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1626 mL10.8131 mL21.6263 mL108.1315 mL
5 mM0.4325 mL2.1626 mL4.3253 mL21.6263 mL
10 mM0.2163 mL1.0813 mL2.1626 mL10.8131 mL
20 mM0.1081 mL0.5407 mL1.0813 mL5.4066 mL
50 mM0.0433 mL0.2163 mL0.4325 mL2.1626 mL
100 mM0.0216 mL0.1081 mL0.2163 mL1.0813 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

WNK-IN-11WNKIN11WNK1WNK IN 11threoninkinaseThreonine proteasesthreonin kinaseSerinekinaseSerine proteasesSerine kinaseSerine endopeptidasesSer/Thr ProteaseInhibitorinhibit
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