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Zharp1-211
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Catalog No. T87664Cas No. 2258671-41-7
Alias Zharp1211
Zharp1-211 is a selective and potent RIPK3 inhibitor that significantly reduces the expression of JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, restores intestinal homeostasis, and inhibits graft-versus-host disease (GVHD) for gastrointestinal inflammation.
Zharp1-211
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Purity: 99.71%
Catalog No. T87664Alias Zharp1211Cas No. 2258671-41-7
Zharp1-211 is a selective and potent RIPK3 inhibitor that significantly reduces the expression of JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, restores intestinal homeostasis, and inhibits graft-versus-host disease (GVHD) for gastrointestinal inflammation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $79 | In Stock | In Stock | |
| 5 mg | $193 | In Stock | In Stock | |
| 10 mg | $297 | In Stock | In Stock | |
| 25 mg | $592 | In Stock | In Stock | |
| 50 mg | $919 | In Stock | In Stock | |
| 100 mg | $1,380 | - | In Stock | |
| 200 mg | $1,860 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $213 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.71%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Zharp1-211 is a selective and potent RIPK3 inhibitor that significantly reduces the expression of JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, restores intestinal homeostasis, and inhibits graft-versus-host disease (GVHD) for gastrointestinal inflammation. |
| In vitro | Zharp1-211 was highly potent for blocking TNF-induced necroptosis in human colon cancer HT-29 cells and mouse fibroblast L929 cells, and reduced IFN-γ–induced STAT1 activation in mouse intestinal crypt cells by affecting the JAK1/STAT1 pathway. [1] |
| In vivo | Oral administration of Zharp1-211 (10 mg/kg) starting on day 7 after T cell transplantation significantly reduced GVHD severity and improved survival in multiple mouse models. Zharp-211 alleviated inflammation in the colon, small intestine, liver, and skin, preserved intestinal stem and Paneth cells, suppressed chemokine expression, reduced alloreactive T and CXCR3⁺ T cells, and inhibited STAT1 activation and necroptosis/apoptosis in the gut. [2] |
| Synonyms | Zharp1211 |
| Molecular Weight | 447.49 |
| Formula | C24H25N5O4 |
| Cas No. | 2258671-41-7 |
| Smiles | O=C(OC1CCOCC1)N2C=3C=C(C=NC3CC2)C=4C=CC5=NC(=CN5C4)NC(=O)C6CC6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (17.88 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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