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Zharp1-211
🥰Excellent
Catalog No. T87664Cas No. 2258671-41-7
Alias Zharp1211
Zharp1-211 is a selective and potent RIPK3 inhibitor that significantly reduces the expression of JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, restores intestinal homeostasis, and inhibits graft-versus-host disease (GVHD) for gastrointestinal inflammation.
Zharp1-211
🥰Excellent
Purity: 99.71%
Catalog No. T87664Alias Zharp1211Cas No. 2258671-41-7
Zharp1-211 is a selective and potent RIPK3 inhibitor that significantly reduces the expression of JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, restores intestinal homeostasis, and inhibits graft-versus-host disease (GVHD) for gastrointestinal inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $83 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $327 | In Stock | |
| 25 mg | $622 | In Stock | |
| 50 mg | $966 | In Stock | |
| 100 mg | $1,450 | In Stock | |
| 200 mg | $1,950 | In Stock |
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CitedSelect Batch
Purity:99.71%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zharp1-211 is a selective and potent RIPK3 inhibitor that significantly reduces the expression of JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, restores intestinal homeostasis, and inhibits graft-versus-host disease (GVHD) for gastrointestinal inflammation. |
| In vitro | Zharp1-211 was highly potent for blocking TNF-induced necroptosis in human colon cancer HT-29 cells and mouse fibroblast L929 cells, and reduced IFN-γ–induced STAT1 activation in mouse intestinal crypt cells by affecting the JAK1/STAT1 pathway. [1] |
| In vivo | Oral administration of Zharp1-211 (10 mg/kg) starting on day 7 after T cell transplantation significantly reduced GVHD severity and improved survival in multiple mouse models. Zharp-211 alleviated inflammation in the colon, small intestine, liver, and skin, preserved intestinal stem and Paneth cells, suppressed chemokine expression, reduced alloreactive T and CXCR3⁺ T cells, and inhibited STAT1 activation and necroptosis/apoptosis in the gut. [2] |
| Alias | Zharp1211 |
| Molecular Weight | 447.49 |
| Formula | C24H25N5O4 |
| Cas No. | 2258671-41-7 |
| Smiles | O=C(OC1CCOCC1)N2C=3C=C(C=NC3CC2)C=4C=CC5=NC(=CN5C4)NC(=O)C6CC6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (17.88 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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