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Anti-MRP2/ABCC2 Polyclonal Antibody (Synonyms: multidrug resistance-associated protein2, Multidrug resistance a...)
Catalog No. TMAB-01169 Copy Product Info
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Anti-MRP2/ABCC2 Polyclonal Antibody is a Rabbit antibody targeting MRP2/ABCC2. Anti-MRP2/ABCC2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P.
Anti-MRP2/ABCC2 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-01169
Synonyms multidrug resistance-associated protein2, Multidrug resistance associated protein 2, MRP2, MRP 2, KIAA1010, DJS, cMRP, CMOAT1, CMOAT, Canalicular multispecific organic anion transporter 1, Canalicular multidrug resistance protein, ATP-binding cassette sub-family C member 2, ATP binding cassette subfamily C member 2, ATP binding cassette sub family C(CFTR/MRP) member 2, ABCC2, ABC30
Anti-MRP2/ABCC2 Polyclonal Antibody is a Rabbit antibody targeting MRP2/ABCC2. Anti-MRP2/ABCC2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P.
Anti-MRP2/ABCC2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Antigen Details
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| Description | Anti-MRP2/ABCC2 Polyclonal Antibody is a Rabbit antibody targeting MRP2/ABCC2. Anti-MRP2/ABCC2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P. |
| Synonyms | multidrug resistance-associated protein2, Multidrug resistance associated protein 2, MRP2, MRP 2, KIAA1010, DJS, cMRP, CMOAT1, CMOAT, Canalicular multispecific organic anion transporter 1, Canalicular multidrug resistance protein, ATP-binding cassette sub-family C member 2, ATP binding cassette subfamily C member 2, ATP binding cassette sub family C(CFTR/MRP) member 2, ABCC2, ABC30 |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MRP2/ABCC2 Polyclonal Antibody, Unconjugated (TMAB-01169) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 2. The A549 (H) cells were fixed with 4% PFA (10 min at room temperature). Primary Antibody (green): Rabbit Anti-MRP2/ABCC2 antibody (TMAB-01169): 1 μg/10^6 cells; Secondary Antibody (white blue): Goat anti-Rabbit IgG-FITC: 1 μg/test. Isotype Control (orange): Rabbit IgG. Blank control (black): PBS.   |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family. |
| Immunogen | KLH conjugated synthetic peptide: human MRP2 |
| Antigen Species | Human |
| Gene Name | ABCC2 |
| Gene ID | |
| Protein Name | Canalicular multispecific organic anion transporter 1 |
| Uniprot ID | |
| Biology Area | MRP-related proteins,Channels |
| Function | Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. |
| Molecular Weight | Theoretical: 174 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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