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CCL4 Protein, Human, Recombinant (His)

Catalog No. TMPY-00646
Synonyms: SCYA2, G-26, MIP-1-β, LAG-1, MIP1B, AT744.1, SCYA4, MIP-1-beta, chemokine (C-C motif) ligand 4, ACT2, MIP1B1, LAG1, HC21

CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. In particular, higher serum CCL4 levels in patients with oral squamous cell carcinoma (OSCC) are associated with a more advanced stage of disease. CCL4 may be a new molecular therapeutic target for inhibition of lymphangiogenesis and metastasis in OSCC. CCL3 and CCL4 loci may be marker SNPs for risk of HCV treatment outcome. CCL4 can enhance the recruitment of preosteoclasts to bone in the early stage, and the reduction of CCR5 promotes osteoclastogenesis when RANKL is prevalent.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CCL4 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 275.00
100 μg 5 days $ 618.00
1 mg 5 days $ 3,910.00
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Biological Description
Technical Params
Product Properties
Description CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. In particular, higher serum CCL4 levels in patients with oral squamous cell carcinoma (OSCC) are associated with a more advanced stage of disease. CCL4 may be a new molecular therapeutic target for inhibition of lymphangiogenesis and metastasis in OSCC. CCL3 and CCL4 loci may be marker SNPs for risk of HCV treatment outcome. CCL4 can enhance the recruitment of preosteoclasts to bone in the early stage, and the reduction of CCR5 promotes osteoclastogenesis when RANKL is prevalent.
Species Human
Expression System Yeast
Tag His
Accession Number P13236
Synonyms SCYA2, G-26, MIP-1-β, LAG-1, MIP1B, AT744.1, SCYA4, MIP-1-beta, chemokine (C-C motif) ligand 4, ACT2, MIP1B1, LAG1, HC21
Construction A DNA sequence encoding human CCL4 (NP_002975.1) (Ala24-Gln92) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity > 90 % as determined by SDS-PAGE
Molecular Weight 9.2 kDa (predicted)
Endotoxin Please contact us for more information.
Formulation Lyophilized from sterile 0. 1 % TFA. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background CCL4 (C-C chemokine ligand 4), is a macrophage inflammatory protein with a chief effect in inflammation and immune-regulation, and was documented in cancer progression by promoting instability in the tumor environment. The inflammatory chemokine (C-C motif) ligand 4 (CCL4) plays an important role in the pathogenesis and progression of cancer. In particular, higher serum CCL4 levels in patients with oral squamous cell carcinoma (OSCC) are associated with a more advanced stage of disease. CCL4 may be a new molecular therapeutic target for inhibition of lymphangiogenesis and metastasis in OSCC. CCL3 and CCL4 loci may be marker SNPs for risk of HCV treatment outcome. CCL4 can enhance the recruitment of preosteoclasts to bone in the early stage, and the reduction of CCR5 promotes osteoclastogenesis when RANKL is prevalent.

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Keywords

CCL4 Protein, Human, Recombinant (His) SCYA2 G-26 LAG 1 MIP-1-β HC-21 SCYA-2 G 26 ACT 2 LAG-1 SCYA-4 MIP1B AT744.1 ACT-2 SCYA4 SCYA 2 MIP-1-beta chemokine (C-C motif) ligand 4 G26 HC 21 ACT2 MIP1B1 SCYA 4 LAG1 HC21 recombinant recombinant-proteins proteins protein

 

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