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KIT-13
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Catalog No. T210994
KIT-13 is an orally active acetal phospholipid derivative that effectively inhibits neuroinflammation and addresses mitochondrial DNA leakage issues associated with Mecp2 deficiency. It significantly alleviates neurological symptoms and prolongs lifespan in Rett Syndrome (RTT) model mice. KIT-13 is valuable for research in RTT and other neuroinflammation-related conditions.
KIT-13
KIT-13
😃Good
Catalog No. T210994
KIT-13 is an orally active acetal phospholipid derivative that effectively inhibits neuroinflammation and addresses mitochondrial DNA leakage issues associated with Mecp2 deficiency. It significantly alleviates neurological symptoms and prolongs lifespan in Rett Syndrome (RTT) model mice. KIT-13 is valuable for research in RTT and other neuroinflammation-related conditions.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | KIT-13 is an orally active acetal phospholipid derivative that effectively inhibits neuroinflammation and addresses mitochondrial DNA leakage issues associated with Mecp2 deficiency. It significantly alleviates neurological symptoms and prolongs lifespan in Rett Syndrome (RTT) model mice. KIT-13 is valuable for research in RTT and other neuroinflammation-related conditions. |
| In vitro | KIT-13 (5-10 g/mL, 48 h, BV2 cells) enhances mitochondrial function impaired by Mecp2 gene deletion and restores mitochondrial membrane potential in Mecp2-knockdown BV2 cells through PK11195 treatment. |
| In vivo | KIT-13 (20 μg/kg, p.o., administered daily for one week) ameliorates neurological symptoms in RTT mice and restores the morphology of healthy microglia in brain tissue. Additionally, KIT-139 (administered orally for two weeks, daily) alleviates social and anxiety-like behavioral abnormalities in RTT model mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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