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UHMCP1

Name: UHMCP1
Brand: TargetMol
SKU: T208218
Rating: 4.5 (1 reviews)

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Catalog No. T208218Cas No. 2103079-87-2

UHMCP1 is a chemical probe of the U2AF homology motif (UHM), with a dissociation constant (Kd) of 79 μM. It inhibits the interaction between SF3b155 and U2AF65, affecting RNA splicing and cell viability. UHMCP1 also possesses potential anticancer properties.

UHMCP1

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Catalog No. T208218Cas No. 2103079-87-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	UHMCP1 is a chemical probe of the U2AF homology motif (UHM), with a dissociation constant (Kd) of 79 μM. It inhibits the interaction between SF3b155 and U2AF65, affecting RNA splicing and cell viability. UHMCP1 also possesses potential anticancer properties.
In vitro	UHMCP1 (25-400 μM) decreases the binding affinity of purified U2AF 65 to SF3b155 by 75%, following a straightforward, non-cooperative binding mechanism with a dissociation constant (K d) of approximately 30 μM for U2AF 65. Additionally, UHMCP1 (0-200 μM; 24 h) impacts the cell viability of HEK293 cells.

Chemical Properties

Molecular Weight	297.44
Formula	C₁₉H₂₇N₃
Cas No.	2103079-87-2
Smiles	C(CC(C)N1C[C@@]2([C@@H](N)[C@](C1)(CC2)[H])[H])C=3C=4C(NC3)=CC=CC4

Storage & Solubility Information

Storage

keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc