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ZD-0892

Name: ZD-0892
Brand: TargetMol
SKU: T13389
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13389Cas No. 171964-73-1

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

ZD-0892

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Purity: 99.53%

Catalog No. T13389Cas No. 171964-73-1

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$176	-	In Stock
10 mg	$290	-	In Stock
25 mg	$538	-	In Stock
50 mg	$738	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.53%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.
Targets&IC50	Neutrophil elastase (pig):200 nM (Ki), Neutrophil elastase (human):6.7 nM (Ki)
In vitro	Neutrophils incubated with ZD-0892 (20µM) for 1 hour were found to be resistant to superoxide, hypochlorite, hydrogen peroxide, hydroxyl radical and peroxynitrite-mediated degradation and had no effect on the formation of these oxidants by activated neutrophils.[3]
In vivo	Administration of ZD0892 to DBA/2 mice infected with EMC virus reduces myocardial elastolytic activity and coronary microvascular perfusion injury.ZD0892 reduces the pathological severity of myocardial lesions associated with viral myocarditis in mice[1].ZD-0892 reverses advanced pulmonary vascular disease produced in rats[2].

Chemical Properties

Molecular Weight	499.52
Formula	C₂₄H₃₂F₃N₃O₅
Cas No.	171964-73-1
Smiles	COc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Relative Density.	1.227 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (300.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0019 mL	10.0096 mL	20.0192 mL	100.0961 mL
5 mM	0.4004 mL	2.0019 mL	4.0038 mL	20.0192 mL
10 mM	0.2002 mL	1.0010 mL	2.0019 mL	10.0096 mL
20 mM	0.1001 mL	0.5005 mL	1.0010 mL	5.0048 mL
50 mM	0.0400 mL	0.2002 mL	0.4004 mL	2.0019 mL
100 mM	0.0200 mL	0.1001 mL	0.2002 mL	1.0010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc