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Setoxaximab is a humanized monoclonal antibody targeting Shiga toxin 2(Stx2). By specifically binding Stx2, it blocks its interaction with Gb3 receptor on the host cell surface and the internalization process of toxin, thus inhibiting ribosome inactivation and reducing cytotoxicity. Setoxaximab can be used in the study of hemolytic uremic syndrome (HUS) and other related diseases.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
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| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
| Description | Setoxaximab is a humanized monoclonal antibody targeting Shiga toxin 2(Stx2). By specifically binding Stx2, it blocks its interaction with Gb3 receptor on the host cell surface and the internalization process of toxin, thus inhibiting ribosome inactivation and reducing cytotoxicity. Setoxaximab can be used in the study of hemolytic uremic syndrome (HUS) and other related diseases. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | Stx1 |
| Cas No. | 1351470-17-1 |
| Isotype | IgG1 |
| Storage | Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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