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KHK-IN-1 hydrochloride

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Catalog No. T15659Cas No. 1303470-48-5

KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.

KHK-IN-1 hydrochloride
Other Forms of KHK-IN-1 hydrochloride:
KHK-IN-1T156601303469-70-6
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KHK-IN-1 hydrochloride

🥰Excellent
Purity: 98.05%
Catalog No. T15659Cas No. 1303470-48-5
KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$999-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.05%
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Product Introduction

Bioactivity
Description
KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.
Targets&IC50
KHK:12nM
In vitro
Methods: HepG2 cells were treated with KHK-IN-1 hydrochloride (0-10 µM) and the level of KHK product F1P in cell lysates was measured using LC-MS quantification of F1P
Results: KHK-IN-1 hydrochloride inhibited the production of F1P in HepG2 cell lysates with an IC50 value of 400 nM.[1]
In vivo
Methods: Rats were treated with KHK-IN-1 hydrochloride (10 mg/kg, oral) for pharmacokinetic studies.
Results: KHK-IN-1 hydrochloride showed reasonable oral bioavailability in rats (F = 34%; oral t1/2 = 4 h); high distribution volume (Vdss = 32 L/kg) and high clearance (CL = 160 mL/min/kg); its plasma Cmax was only 0.16 μM.[2]
Chemical Properties
Molecular Weight459.01
FormulaC21H27ClN8S
Cas No.1303470-48-5
SmilesCl.N=1C=NC=2C(=NC(=NC2C1NCC3CC3)N4CCNCC4)NC=5C=CC=CC5SC
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (43.57 mM), Sonication is recommended.
H2O: 10 mg/mL (21.79 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.36 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.1786 mL10.8930 mL21.7860 mL108.9301 mL
5 mM0.4357 mL2.1786 mL4.3572 mL21.7860 mL
10 mM0.2179 mL1.0893 mL2.1786 mL10.8930 mL
20 mM0.1089 mL0.5447 mL1.0893 mL5.4465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KHK-IN-1 HydrochlorideKHKIN1 hydrochlorideKHK IN 1 hydrochloride
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