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KHK-IN-1 hydrochloride

Name: KHK-IN-1 hydrochloride
Brand: TargetMol
SKU: T15659
Price: 999 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15659Cas No. 1303470-48-5

KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.

KHK-IN-1 hydrochloride

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Purity: 98.05%

Catalog No. T15659Cas No. 1303470-48-5

KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$999	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.05%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	KHK-IN-1 hydrochloride is a selective, cell-permeable, and efficient hexokinase (KHK) inhibitor, useful for studying diabetes and obesity.
Targets&IC50	KHK:12nM
In vitro	Methods: HepG2 cells were treated with KHK-IN-1 hydrochloride (0-10 µM) and the level of KHK product F1P in cell lysates was measured using LC-MS quantification of F1P Results: KHK-IN-1 hydrochloride inhibited the production of F1P in HepG2 cell lysates with an IC50 value of 400 nM.[1]
In vivo	Methods: Rats were treated with KHK-IN-1 hydrochloride (10 mg/kg, oral) for pharmacokinetic studies. Results: KHK-IN-1 hydrochloride showed reasonable oral bioavailability in rats (F = 34%; oral t1/2 = 4 h); high distribution volume (Vdss = 32 L/kg) and high clearance (CL = 160 mL/min/kg); its plasma Cmax was only 0.16 μM.[2]

Chemical Properties

Molecular Weight	459.01
Formula	C₂₁H₂₇ClN₈S
Cas No.	1303470-48-5
Smiles	Cl.N=1C=NC=2C(=NC(=NC2C1NCC3CC3)N4CCNCC4)NC=5C=CC=CC5SC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (43.57 mM), Sonication is recommended.

H2O: 10 mg/mL (21.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1786 mL	10.8930 mL	21.7860 mL	108.9301 mL
5 mM	0.4357 mL	2.1786 mL	4.3572 mL	21.7860 mL
10 mM	0.2179 mL	1.0893 mL	2.1786 mL	10.8930 mL
20 mM	0.1089 mL	0.5447 mL	1.0893 mL	5.4465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KHK-IN-1 HydrochlorideKHKIN1 hydrochlorideKHK IN 1 hydrochloride