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Tenapanor

Name: Tenapanor
Brand: TargetMol
SKU: T7587
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7587Cas No. 1234423-95-0

Alias Tenapanor free base, RDX-5791, RDX5791, RDX 5791, AZD-1722, AZD1722, AZD 1722

Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and, as of now, there are no serious concerns about its side effects.

Tenapanor

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Purity: 99.85%

Catalog No. T7587Alias Tenapanor free base, RDX-5791, RDX5791, RDX 5791, AZD-1722, AZD1722, AZD 1722Cas No. 1234423-95-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$117	In Stock	In Stock
25 mg	$239	In Stock	In Stock
50 mg	$378	In Stock	In Stock
100 mg	$577	-	In Stock
1 mL x 10 mM (in DMSO)	$312	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Tenapanor AI Summary

Tenapanor exhibits notable bioactivity as an inhibitor of NHE3 (sodium-hydrogen exchanger 3), showing IC50 values of 9.333 nM and 5.012 nM for rat and human NHE3, respectively, in Opossum kidney cells. It alters phosphate and sodium levels in the urine of Sprague-Dawley rats, demonstrating dose-dependent effects when administered orally. Additionally, in vivo studies revealed that the compound impacts sodium absorption from the intestine and decreases urinary sodium and potassium concentrations. Tenapanor also exhibits minimal inhibitory activity on the SARS-CoV-2 3CL-Pro protease and shows limited antiviral activity against SARS-CoV-2 in VERO-6 cells, with inhibition percentages of -1.52% and -0.09% at 20 µM and 10 µM, respectively. Furthermore, it demonstrates a high drug recovery rate of 92.0% in rat feces, with a Cmax of less than 2.62 nM in Sprague-Dawley rats. The compound shows less than 50.0% inhibition of human ERG at 10 µM. These findings suggest potential therapeutic uses of Tenapanor in conditions related to phosphate and sodium homeostasis and modulating NHE3 function..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tenapanor (RDX 5791) is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and, as of now, there are no serious concerns about its side effects.
Targets&IC50	NHE3 (rat):10 nM (IC50), NHE3 (human):5 nM (IC50)
Synonyms	Tenapanor free base, RDX-5791, RDX5791, RDX 5791, AZD-1722, AZD1722, AZD 1722

Chemical Properties

Molecular Weight	1145.05
Formula	C₅₀H₆₆Cl₄N₈O₁₀S₂
Cas No.	1234423-95-0
Smiles	CN1C[C@@H](c2cccc(c2)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)c2cccc(c2)[C@@H]2CN(C)Cc3c(Cl)cc(Cl)cc23)c2cc(Cl)cc(Cl)c2C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (131 mM), Sonication is recommended.

H2O: < 0.1 mg/mL (insoluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8733 mL	4.3666 mL	8.7332 mL	43.6662 mL
5 mM	0.1747 mL	0.8733 mL	1.7466 mL	8.7332 mL
10 mM	0.0873 mL	0.4367 mL	0.8733 mL	4.3666 mL
20 mM	0.0437 mL	0.2183 mL	0.4367 mL	2.1833 mL
50 mM	0.0175 mL	0.0873 mL	0.1747 mL	0.8733 mL
100 mM	0.0087 mL	0.0437 mL	0.0873 mL	0.4367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc