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D-JNKI-1

Name: D-JNKI-1
Brand: TargetMol
SKU: T10937
Rating: 4.5 (1 reviews)

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Catalog No. T10937Cas No. 1445179-97-4

Alias XG-102, AM-111

D-JNKI-1 (AM-111) is a highly effective, cell-permeable peptide inhibitor.

D-JNKI-1

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Catalog No. T10937Alias XG-102, AM-111Cas No. 1445179-97-4

D-JNKI-1 (AM-111) is a highly effective, cell-permeable peptide inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$1,140	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	D-JNKI-1 (AM-111) is a highly effective, cell-permeable peptide inhibitor.
In vitro	D-JNKI-1 (AM-111; 1μM-1mM) treatment can prevent neomycin-induced apoptosis and loss of hair cells.
In vivo	D-JNKI-1 (AM-111; 10μM) effectively prevents hair cell death and permanent hearing loss induced by neomycin ototoxicity in guinea pig cochlea mp. Local delivery of D-JNKI-1 also mitigates permanent hearing loss due to hearing trauma in a dose-dependent manner. D-JNKI-1 (0.3 mg/kg, intraperitoneal injection) reverses pathological events in rat brain mitochondria, significantly reducing cytochrome c release and PARP cleavage. Additionally, D-JNKI-1 (1 μg/kg, s.c.) substantially decreases the disease activity index and reduces CD4+ and CD8+ cell expression in mice.
Synonyms	XG-102, AM-111

Chemical Properties

Molecular Weight	3822.44
Formula	C₁₆₄H₂₈₆N₆₆O₄₀
Cas No.	1445179-97-4
Relative Density.	no data available
Sequence	{d-(Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly)}-NH2
Sequence Short	{d-(Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly)}-NH2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (13.08 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.2616 mL	1.3081 mL	2.6161 mL	13.0807 mL
5 mM	0.0523 mL	0.2616 mL	0.5232 mL	2.6161 mL
10 mM	0.0262 mL	0.1308 mL	0.2616 mL	1.3081 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc