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KPLH1130

Name: KPLH1130
Brand: TargetMol
SKU: T11765
Price: 76 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11765Cas No. 906669-07-6

KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.

KPLH1130

🥰Excellent

Purity: 99.07%

Catalog No. T11765Cas No. 906669-07-6

Pack Size	Price	Availability
1 mg	$76	In Stock
5 mg	$228	In Stock
10 mg	$369	In Stock
25 mg	$622	In Stock
50 mg	$885	In Stock
100 mg	$1,190	In Stock
500 mg	$2,430	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Batch Information

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Purity:99.07%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	283.28
Formula	C₁₅H₁₃N₃O₃
Cas No.	906669-07-6
Smiles	Cc1ccc(cc1)-n1c(n[nH]c1=O)-c1ccc(O)cc1O
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (458.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5301 mL	17.6504 mL	35.3008 mL	176.5038 mL
5 mM	0.7060 mL	3.5301 mL	7.0602 mL	35.3008 mL
10 mM	0.3530 mL	1.7650 mL	3.5301 mL	17.6504 mL
20 mM	0.1765 mL	0.8825 mL	1.7650 mL	8.8252 mL
50 mM	0.0706 mL	0.3530 mL	0.7060 mL	3.5301 mL
100 mM	0.0353 mL	0.1765 mL	0.3530 mL	1.7650 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc