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SS-RJW100

Catalog No. T61723

SS-RJW100 is an enantiomer of RJW100, known as a racemic agonist that targets two nuclear receptors: liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). In vitro experiments reveal that SS-RJW100 promotes the recruitment of coregulator protein fragments and enhances the interaction with the transcriptional intermediary factor 2 (Tif2) coactivator specifically for LRH-1. Additionally, SS-RJW100 disrupts the allosteric activation networks of LRH-1, displaying suboptimal thermal stability [1] [2].

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SS-RJW100, CAS N/A

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Liver receptor homolog-1 (LRH-1) and steroidogenic factor-1 (SF-1), which are essential nuclear hormone receptors (NR) involved in regulating metabolism, inflammation, and cell proliferation, are specifically targeted by SS-RJW100. This compound demonstrates selective affinity towards LRH-1 and SF-1, displaying Ki values of 1.2 μM and 30 μM, respectively. Upon treatment with SS-RJW100 at a concentration of 30 μM for 24 hours, an increase in LRH-1 transcriptional activity is observed in Hela cells overexpressing both wild-type and mutant forms of LRH-1 (T352V, H390A, A349F), indicating the compound's efficacy is unaffected by these mutations. This suggests SS-RJW100's potential in activating LRH-1 dependent transcription in various cellular environments without being hindered by common LRH-1 mutations.

Molecular Weight	386.57
Formula	C28H34O

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SS-RJW100 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.