Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS6105 is a chimeric LDH protein hydrolysis-targeted PROTAC that degrades LDHA and LDHB efficiently, with its activity contingent on both time and the ubiquitin-proteasome system, exhibiting anticancer properties [1]. Additionally, as a click chemistry reagent possessing an Alkyne group, MS6105 can partake in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide-bearing molecules.
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Description | MS6105 is a chimeric LDH protein hydrolysis-targeted PROTAC that degrades LDHA and LDHB efficiently, with its activity contingent on both time and the ubiquitin-proteasome system, exhibiting anticancer properties [1]. Additionally, as a click chemistry reagent possessing an Alkyne group, MS6105 can partake in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Azide-bearing molecules. |
In vitro | MS6105 (compound 22), when administered at concentrations ranging from 10 nM to 10 μM over 48 hours, effectively induces time- and concentration-dependent degradation of LDHA and LDHB in PANC1 cells, exhibiting DC50 values of 38 nM for LDHA and 74 nM for LDHB, respectively [1]. |
Molecular Weight | 1228.59 |
Formula | C65H81N9O9S3 |
CAS No. | 2891709-58-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MS6105 2891709-58-1 PROTAC PROTACs inhibitor inhibit