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Indole-3-butyric acid

Name: Indole-3-butyric acid
Brand: TargetMol
SKU: T6361
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6361Cas No. 133-32-4

Alias IBA, Hormodin, 3-Indolebutyric acid

Indole-3-butyric acid (IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.

Indole-3-butyric acid

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Purity: 99.92%

Catalog No. T6361Alias IBA, Hormodin, 3-Indolebutyric acidCas No. 133-32-4

Indole-3-butyric acid (IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$41	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Indole-3-butyric acid AI Summary

Indole-3-butyric acid exhibits a broad spectrum of bioactivities. It acts as an antagonist at the human T1R2/T1R3 receptor with an IC50 value greater than 1,000,000 nM, inhibiting sucralose-induced intracellular calcium mobilization in HEK293E cells. In receptor-based assays, it shows agonist activity towards retinoid X receptor alpha, estrogen receptor alpha, androgen receptor, peroxisome proliferator-activated receptor delta and gamma, and the ARE signaling pathways, with potencies ranging from 13.3 nM to 61,130.6 nM. It also displays antagonist activity towards the androgen receptor. For enzymatic inhibition, Indole-3-butyric acid inhibits electric eel AChE (-10.87%) and horse BChE (-5.54%) at 2 mg/mL. In terms of antibacterial properties, it inhibits metallo-beta-lactamase VIM-2 from Pseudomonas aeruginosa, with an IC50 of 757,000 nM and Kd of 274,000 nM, as well as Klebsiella pneumoniae NDM-1 with an IC50 of 1,946,000 nM and Kd of 806,000 nM. Moreover, it shows activity against Klebsiella pneumoniae OXA-48 (IC50 of 480,000 nM, Kd of 430,000 nM) and LOX with an IC50 of 17,820 nM. In antiviral assays, Indole-3-butyric acid inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 16.23% at 10 µM after 48 hours, but demonstrates significantly lower inhibition in VERO-6 cells (-0.05%). For SARS-CoV-2 3CL-Pro protease, it shows 1.767% inhibition at 20 µM. Additionally, it has fungicidal activity against various fungi like Macrophomina phaseoli, Rhizoctonia solani, Pythium debaryanum, and Fusarium culmorum with IC50 values ranging from 249.0 to 699.0 µg/mL, and promotes root formation in Vigna mungo cuttings at 1 x 10^-4 M, matching the activity of IBA. Finally, it exhibits inhibitory activity against the human HDAC6 enzyme with -15.75% inhibition in one enzymatic assay and -2.0% in another..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Indole-3-butyric acid (IBA) is a plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
Synonyms	IBA, Hormodin, 3-Indolebutyric acid

Chemical Properties

Molecular Weight	203.24
Formula	C₁₂H₁₃NO₂
Cas No.	133-32-4
Smiles	OC(=O)CCCC1=CNC2=CC=CC=C12
Relative Density.	1.1255 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 39 mg/mL (191.89 mM), Sonication is recommended.

DMSO: 50 mg/mL (246.01 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (12.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9203 mL	24.6015 mL	49.2029 mL	246.0146 mL
5 mM	0.9841 mL	4.9203 mL	9.8406 mL	49.2029 mL
10 mM	0.4920 mL	2.4601 mL	4.9203 mL	24.6015 mL
20 mM	0.2460 mL	1.2301 mL	2.4601 mL	12.3007 mL
50 mM	0.0984 mL	0.4920 mL	0.9841 mL	4.9203 mL
100 mM	0.0492 mL	0.2460 mL	0.4920 mL	2.4601 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc