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SJ995973

Name: SJ995973
Brand: TargetMol
SKU: T77933
Price: 137 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77933Cas No. 2882065-25-8

Alias SJ-995973, SJ 995973

SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.

SJ995973

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Purity: 99.36%

Catalog No. T77933Alias SJ-995973, SJ 995973Cas No. 2882065-25-8

SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$137	-	In Stock
5 mg	$413	-	In Stock
10 mg	$708	-	In Stock
25 mg	$1,060	-	In Stock
50 mg	$1,420	-	In Stock
100 mg	$1,920	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.36%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.
Targets&IC50	BRD4:0.87 nM (DC50), MV-4-11 cells:3 pM
In vitro	SJ995973 was a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins. SJ995973 inhibited the viability of human acute myeloid leukemia MV4-11 cells at low picomolar concentrations, IC50 = 3 pM, BRD4 DC50 = 0.87 nM. [1]
Synonyms	SJ-995973, SJ 995973

Chemical Properties

Molecular Weight	730.28
Formula	C₃₇H₄₀ClN₇O₅S
Cas No.	2882065-25-8
Smiles	CC=1C2=C(N3C([C@H](CC(NCCCCCNC(COC4=CC=C(C=C4)C5C(=O)NC(=O)CC5)=O)=O)N=C2C6=CC=C(Cl)C=C6)=NN=C3C)SC1C

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (109.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3693 mL	6.8467 mL	13.6934 mL	68.4669 mL
5 mM	0.2739 mL	1.3693 mL	2.7387 mL	13.6934 mL
10 mM	0.1369 mL	0.6847 mL	1.3693 mL	6.8467 mL
20 mM	0.0685 mL	0.3423 mL	0.6847 mL	3.4233 mL
50 mM	0.0274 mL	0.1369 mL	0.2739 mL	1.3693 mL
100 mM	0.0137 mL	0.0685 mL	0.1369 mL	0.6847 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc