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SJ995973

Name: SJ995973
Brand: TargetMol
SKU: T77933
Price: 228 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77933Cas No. 2882065-25-8

Alias SJ-995973, SJ 995973

SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.

SJ995973

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Purity: 99.36%

Catalog No. T77933Alias SJ-995973, SJ 995973Cas No. 2882065-25-8

SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$228	-	In Stock
5 mg	$689	-	In Stock
10 mg	$1,180	-	In Stock
25 mg	$1,780	-	In Stock
50 mg	$2,380	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.36%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SJ995973 is a highly potent bromodomain and extraterminal (BET) protein degrader and a BET PROTAC with potential anticancer activity.
Targets&IC50	MV4-11 cells:3 pM, BRD4:0.87 nM (DC50)
In vitro	SJ995973 was a uniquely potent degrader of bromodomain and extra-terminal (BET) proteins. SJ995973 inhibited the viability of human acute myeloid leukemia MV4-11 cells at low picomolar concentrations, IC50 = 3 pM, BRD4 DC50 = 0.87 nM. [1]
Synonyms	SJ-995973, SJ 995973

Chemical Properties

Molecular Weight	730.28
Formula	C₃₇H₄₀ClN₇O₅S
Cas No.	2882065-25-8
Smiles	CC=1C2=C(N3C([C@H](CC(NCCCCCNC(COC4=CC=C(C=C4)C5C(=O)NC(=O)CC5)=O)=O)N=C2C6=CC=C(Cl)C=C6)=NN=C3C)SC1C

Storage & Solubility Information

Storage

store under nitrogen | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL(109.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3693 mL	6.8467 mL	13.6934 mL	68.4669 mL
5 mM	0.2739 mL	1.3693 mL	2.7387 mL	13.6934 mL
10 mM	0.1369 mL	0.6847 mL	1.3693 mL	6.8467 mL
20 mM	0.0685 mL	0.3423 mL	0.6847 mL	3.4233 mL
50 mM	0.0274 mL	0.1369 mL	0.2739 mL	1.3693 mL
100 mM	0.0137 mL	0.0685 mL	0.1369 mL	0.6847 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc