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FT827

Name: FT827
Brand: TargetMol
SKU: T15351
Price: 238 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15351Cas No. 1959537-86-0

FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.

FT827

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Purity: 98.76%

Catalog No. T15351Cas No. 1959537-86-0

Pack Size	Price	Availability
1 mg	$238	In Stock
5 mg	$582	In Stock
10 mg	$719	In Stock
25 mg	$948	In Stock
50 mg	$1,180	In Stock
100 mg	$1,580	In Stock
200 mg	$2,160	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.76%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.
Targets&IC50	USP7:（kd）7.8 μM, USP7:（ki）4.2 μM
In vitro	After incubating MCF7 cell extracts with DMSO, 1 µM or 10 µM of FT671, FT827, or 50 µM of P22077 for 60 minutes, the results demonstrated the target-specific engagement of USP7 in MCF7 cells[1].

Chemical Properties

Molecular Weight	548.61
Formula	C₂₇H₂₈N₆O₅S
Cas No.	1959537-86-0
Smiles	Cn1ncc2c1ncn(CC1(O)CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1NS(=O)(=O)C=C)c2=O
Relative Density.	1.42 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (145.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8228 mL	9.1139 mL	18.2279 mL	91.1394 mL
5 mM	0.3646 mL	1.8228 mL	3.6456 mL	18.2279 mL
10 mM	0.1823 mL	0.9114 mL	1.8228 mL	9.1139 mL
20 mM	0.0911 mL	0.4557 mL	0.9114 mL	4.5570 mL
50 mM	0.0365 mL	0.1823 mL	0.3646 mL	1.8228 mL
100 mM	0.0182 mL	0.0911 mL	0.1823 mL	0.9114 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc