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FT827

Name: FT827
Brand: TargetMol
SKU: T15351
Price: 238 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15351Cas No. 1959537-86-0

FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.

FT827

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Purity: 98.76%

Catalog No. T15351Cas No. 1959537-86-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$238	In Stock	In Stock
5 mg	$582	In Stock	In Stock
10 mg	$719	-	In Stock
25 mg	$948	-	In Stock
50 mg	$1,180	-	In Stock
100 mg	$1,580	-	In Stock
200 mg	$2,160	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.76%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.
Targets&IC50	USP7:（kd）7.8 μM, USP7:（ki）4.2 μM
In vitro	After incubating MCF7 cell extracts with DMSO, 1 µM or 10 µM of FT671, FT827, or 50 µM of P22077 for 60 minutes, the results demonstrated the target-specific engagement of USP7 in MCF7 cells[1].

Chemical Properties

Molecular Weight	548.61
Formula	C₂₇H₂₈N₆O₅S
Cas No.	1959537-86-0
Smiles	Cn1ncc2c1ncn(CC1(O)CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1NS(=O)(=O)C=C)c2=O
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (145.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8228 mL	9.1139 mL	18.2279 mL	91.1394 mL
5 mM	0.3646 mL	1.8228 mL	3.6456 mL	18.2279 mL
10 mM	0.1823 mL	0.9114 mL	1.8228 mL	9.1139 mL
20 mM	0.0911 mL	0.4557 mL	0.9114 mL	4.5570 mL
50 mM	0.0365 mL	0.1823 mL	0.3646 mL	1.8228 mL
100 mM	0.0182 mL	0.0911 mL	0.1823 mL	0.9114 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc