Apoptosisinducer 17 is a hybrid molecule of Curcumin-Piperlongumine that enhances cell cycle arrest and apoptosis (apoptosis) in lung cancer cells by activating the JNK signaling pathway.

Apoptosis inducer 17 (compound CP; 0.027-60 μM; 72 h) effectively inhibits cell proliferation with IC50 values of 0.021 μM, 0.027 μM, and 0.73 μM for H446, H1299, and SBC-2 cells, respectively. It demonstrates significant colony formation inhibition at 0.03-0.3 μM over 24 hours. JNK-IN-17 induces dose-dependent G2/M phase arrest in H446 and H1299 cells. Additionally, Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 hours) promotes apoptosis in H446 and H1299 cells mediated by caspase activity and activates the JNK signaling cascade.

Compound CP, administered at 10 mg/kg via intraperitoneal injection twice daily for 15 days, significantly reduced H446 cell growth without causing notable changes in body weight.