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YUKA1

🥰Excellent
Catalog No. T17278Cas No. 708991-09-7
Alias YUKA 1

YUKA1, a cell-permeable KDM5A inhibitor (IC50=2.66 μM) with a weak effect on KDM5C (IC50=7.12 μM) and no effect on other KDM isoforms, was able to increase the level of H3K4me3 in human cells and inhibit the proliferation of cancer cells, and also prevented the emergence of drug-resistant cells.

YUKA1

YUKA1

🥰Excellent
Purity: 99.85%
Catalog No. T17278Alias YUKA 1Cas No. 708991-09-7
YUKA1, a cell-permeable KDM5A inhibitor (IC50=2.66 μM) with a weak effect on KDM5C (IC50=7.12 μM) and no effect on other KDM isoforms, was able to increase the level of H3K4me3 in human cells and inhibit the proliferation of cancer cells, and also prevented the emergence of drug-resistant cells.
Pack SizePriceAvailabilityQuantity
1 mg$370In Stock
5 mg$810In Stock
10 mg$1,216In Stock
25 mg$1,520In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
1 mL x 10 mM (in DMSO)$297In Stock
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Purity:99.85%
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Product Introduction

Bioactivity
Description
YUKA1, a cell-permeable KDM5A inhibitor (IC50=2.66 μM) with a weak effect on KDM5C (IC50=7.12 μM) and no effect on other KDM isoforms, was able to increase the level of H3K4me3 in human cells and inhibit the proliferation of cancer cells, and also prevented the emergence of drug-resistant cells.
In vitro
YUKA1 selectively inhibits NEK2 autophosphorylation in human cancer cell lines (e.g., MDA-MB-231, BT20, MCF7), leading to mitotic arrest, spindle defects, polyploidy, and increased apoptosis at 10-30 μM (24-48 h). YUKA1 also enhances paclitaxel sensitivity[1].
AliasYUKA 1
Chemical Properties
Molecular Weight292.36
FormulaC13H16N4O2S
Cas No.708991-09-7
SmilesS=C1NN=CN1NCC=2C=CC=C(OC)C2OCC=C
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (273.64 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4204 mL17.1022 mL34.2044 mL171.0220 mL
5 mM0.6841 mL3.4204 mL6.8409 mL34.2044 mL
10 mM0.3420 mL1.7102 mL3.4204 mL17.1022 mL
20 mM0.1710 mL0.8551 mL1.7102 mL8.5511 mL
50 mM0.0684 mL0.3420 mL0.6841 mL3.4204 mL
100 mM0.0342 mL0.1710 mL0.3420 mL1.7102 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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