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YUKA1

Name: YUKA1
Brand: TargetMol
SKU: T17278
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17278Cas No. 708991-09-7

Alias YUKA 1

YUKA1, a cell-permeable KDM5A inhibitor (IC50=2.66 μM) with a weak effect on KDM5C (IC50=7.12 μM) and no effect on other KDM isoforms, was able to increase the level of H3K4me3 in human cells and inhibit the proliferation of cancer cells, and also prevented the emergence of drug-resistant cells.

YUKA1

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Purity: 99.85%

Catalog No. T17278Alias YUKA 1Cas No. 708991-09-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	-	In Stock
5 mg	$278	-	In Stock
10 mg	$455	-	In Stock
25 mg	$892	-	In Stock
50 mg	$1,360	-	In Stock
100 mg	$1,980	-	In Stock
200 mg	$2,730	-	In Stock
1 mL x 10 mM (in DMSO)	$297	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	YUKA1, a cell-permeable KDM5A inhibitor (IC50=2.66 μM) with a weak effect on KDM5C (IC50=7.12 μM) and no effect on other KDM isoforms, was able to increase the level of H3K4me3 in human cells and inhibit the proliferation of cancer cells, and also prevented the emergence of drug-resistant cells.
In vitro	YUKA1 selectively inhibits NEK2 autophosphorylation in human cancer cell lines (e.g., MDA-MB-231, BT20, MCF7), leading to mitotic arrest, spindle defects, polyploidy, and increased apoptosis at 10-30 μM (24-48 h). YUKA1 also enhances paclitaxel sensitivity[1].
Synonyms	YUKA 1

Chemical Properties

Molecular Weight	292.36
Formula	C₁₃H₁₆N₄O₂S
Cas No.	708991-09-7
Smiles	S=C1NN=CN1NCC=2C=CC=C(OC)C2OCC=C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (273.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4204 mL	17.1022 mL	34.2044 mL	171.0220 mL
5 mM	0.6841 mL	3.4204 mL	6.8409 mL	34.2044 mL
10 mM	0.3420 mL	1.7102 mL	3.4204 mL	17.1022 mL
20 mM	0.1710 mL	0.8551 mL	1.7102 mL	8.5511 mL
50 mM	0.0684 mL	0.3420 mL	0.6841 mL	3.4204 mL
100 mM	0.0342 mL	0.1710 mL	0.3420 mL	1.7102 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc