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YUKA1, a cell-permeable KDM5A inhibitor (IC50=2.66 μM) with a weak effect on KDM5C (IC50=7.12 μM) and no effect on other KDM isoforms, was able to increase the level of H3K4me3 in human cells and inhibit the proliferation of cancer cells, and also prevented the emergence of drug-resistant cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $370 | In Stock | |
5 mg | $810 | In Stock | |
10 mg | $1,216 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | YUKA1, a cell-permeable KDM5A inhibitor (IC50=2.66 μM) with a weak effect on KDM5C (IC50=7.12 μM) and no effect on other KDM isoforms, was able to increase the level of H3K4me3 in human cells and inhibit the proliferation of cancer cells, and also prevented the emergence of drug-resistant cells. |
In vitro | YUKA1 selectively inhibits NEK2 autophosphorylation in human cancer cell lines (e.g., MDA-MB-231, BT20, MCF7), leading to mitotic arrest, spindle defects, polyploidy, and increased apoptosis at 10-30 μM (24-48 h). YUKA1 also enhances paclitaxel sensitivity[1]. |
Alias | YUKA 1 |
Molecular Weight | 292.36 |
Formula | C13H16N4O2S |
Cas No. | 708991-09-7 |
Smiles | S=C1NN=CN1NCC=2C=CC=C(OC)C2OCC=C |
Relative Density. | no data available |
Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (273.64 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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