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Quinpirole Hydrochloride

Name: Quinpirole Hydrochloride
Brand: TargetMol
SKU: T12606
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12606Cas No. 85798-08-9

Alias LY 171555, (-)-LY 171555

Quinpirole Hydrochloride (LY 171555), as an agonist with high affinity for dopamine receptor D2/D3, has been widely used to study the function of dopamine receptor D2/D3 in humans and mice

Quinpirole Hydrochloride

🥰Excellent

Purity: 98%

Catalog No. T12606Alias LY 171555, (-)-LY 171555Cas No. 85798-08-9

Quinpirole Hydrochloride (LY 171555), as an agonist with high affinity for dopamine receptor D2/D3, has been widely used to study the function of dopamine receptor D2/D3 in humans and mice

Pack Size	Price	Availability	Quantity
1 mg	$99	In Stock

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Purity:98%

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Product Introduction

Bioactivity

Description	Quinpirole Hydrochloride (LY 171555), as an agonist with high affinity for dopamine receptor D2/D3, has been widely used to study the function of dopamine receptor D2/D3 in humans and mice
In vivo	Examined the functions of the DA D1 receptor (D1R) and DA D2 receptor (D2R) by intrastriatal injection of the D1R agonist SKF38393 and the D2R agonist quinpirole. At threshold doses, quinpirole (1.0 μg/site) produce a dose-dependent increase in locomotor activity compared to vehicle injection，in 6-hydroxydopamine (6-OHDA)-lesioned and control rat[1].
Synonyms	LY 171555, (-)-LY 171555

Chemical Properties

Molecular Weight	255.79
Formula	C₁₃H₂₂ClN₃
Cas No.	85798-08-9
Smiles	Cl.[H][C@]12CCCN(CCC)[C@]1([H])Cc1cn[nH]c1C2
Relative Density.	1.07g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 45.0 mg/mL (175.9 mM), Sonication is recommended.

DMSO: 25.0 mg/mL (97.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.9095 mL	19.5473 mL	39.0946 mL	195.4728 mL
5 mM	0.7819 mL	3.9095 mL	7.8189 mL	39.0946 mL
10 mM	0.3909 mL	1.9547 mL	3.9095 mL	19.5473 mL
20 mM	0.1955 mL	0.9774 mL	1.9547 mL	9.7736 mL
50 mM	0.0782 mL	0.3909 mL	0.7819 mL	3.9095 mL

H2O

	1mg	5mg	10mg	50mg
100 mM	0.0391 mL	0.1955 mL	0.3909 mL	1.9547 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc