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CHPG sodium salt

Name: CHPG sodium salt
Brand: TargetMol
SKU: T10808
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10808Cas No. 1303993-73-8

CHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.

CHPG sodium salt

🥰Excellent

Catalog No. T10808Cas No. 1303993-73-8

CHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:>99.99%

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COA IC LCMS HNMR

Product Introduction

Bioactivity

Description	CHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.
In vitro	After the treatment of SO2 derivatives, CHPG sodium salt (10-500 µM) increases the cell viability and decreases the release of LDH. CHPG sodium salt (0.5 mM) prevents SO2-induced apoptosis and increases the expression of TSG-6 through TSG-6/NF-κB pathway in BV2 cells[1].
In vivo	In Sprague-Dawley male rats, injection of CHPG sodium salt (250 nM) reduces the cerebral lesion volume significantly[2].

Chemical Properties

Molecular Weight	223.59
Formula	C₈H₇ClNNaO₃
Cas No.	1303993-73-8
Smiles	C1=CC(=C(C=C1O)C(C(=O)[O-])N)Cl.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 6.0 mg/mL (26.8 mM), Sonication and heating to 80℃ are recommended.

DMSO: 90.0 mg/mL (402.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (14.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4725 mL	22.3624 mL	44.7247 mL	223.6236 mL
5 mM	0.8945 mL	4.4725 mL	8.9449 mL	44.7247 mL
10 mM	0.4472 mL	2.2362 mL	4.4725 mL	22.3624 mL
20 mM	0.2236 mL	1.1181 mL	2.2362 mL	11.1812 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0894 mL	0.4472 mL	0.8945 mL	4.4725 mL
100 mM	0.0447 mL	0.2236 mL	0.4472 mL	2.2362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc