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(R)-Thalidomide

Name: (R)-Thalidomide
Brand: TargetMol
SKU: T12644
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12644Cas No. 2614-06-4

Alias (R)-(+)-Thalidomide

(R)-Thalidomide is a COX 1/2 inhibitor that induces apoptosis in MCF-7, IM-9, HS-Sultan, KB and other cancer cells.

(R)-Thalidomide

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Purity: 99.87%

Catalog No. T12644Alias (R)-(+)-ThalidomideCas No. 2614-06-4

(R)-Thalidomide is a COX 1/2 inhibitor that induces apoptosis in MCF-7, IM-9, HS-Sultan, KB and other cancer cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	-	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$228	In Stock	In Stock
25 mg	$389	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.87%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	(R)-Thalidomide is a COX 1/2 inhibitor that induces apoptosis in MCF-7, IM-9, HS-Sultan, KB and other cancer cells.
In vitro	With the affinity of (R)-Thalidomide by the MIP present surface capture, that is more strongly than the other forms. In the case of (R)-Thalidomide, it is found to bind to the selective sites of the MIP more strongly than the other which reflects their different biological entities[1]. The (S)-Thalidomide imprints MIP nanoparticles exerted a greater cytotoxic effect on the caco-2 cells than the (R)-Thalidomide imprinted MIPs[1].
In vivo	Methods: Adult female F344 rats were implanted with 9L gliosarcoma tumors intracranially, subcutaneously (flank), or both. The efficacy of oral thalidomide alone and in combination with intraperitoneal BCNU or cisplatin was evaluated after several weeks of treatment. S- and (R)-Thalidomide were measured by chiral HPLC in presumed pseudo-steady-state serum, tumor, and other tissues collected after treatment. Results: Serum and tissue concentrations of (R)-Thalidomide were 40-50% higher than those of (S)-Thalidomide. [1]
Synonyms	(R)-(+)-Thalidomide

Chemical Properties

Molecular Weight	258.23
Formula	C₁₃H₁₀N₂O₄
Cas No.	2614-06-4
Smiles	O=C1N(C(=O)C=2C1=CC=CC2)[C@H]3C(=O)NC(=O)CC3
Relative Density.	1.503g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (38.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8725 mL	19.3626 mL	38.7252 mL	193.6258 mL
5 mM	0.7745 mL	3.8725 mL	7.7450 mL	38.7252 mL
10 mM	0.3873 mL	1.9363 mL	3.8725 mL	19.3626 mL
20 mM	0.1936 mL	0.9681 mL	1.9363 mL	9.6813 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc