Home Tools
Log in
Products Inhibitors Libraries Recombinant Proteins Kits Services Contact Us
Cart
Peptides Monoclonal Antibodies Dye Reagents PROTAC Virtual Screening TargetMol Kits Cell Counting Kit-8 (CCK-8) Inhibitor Cocktails Natural Products Phenols Alkaloids Flavonoids
Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library
TargetMol
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

Cuproptosis Compound Library

Catalog No. L8710
  Library Compound List   Excel SDF

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms (Tsvetkov et al., 2022). The mechanism of cuproptosis (copper-dependent death), is significantly different from other known cell death such as apoptosis, pyroptosis, necrosis and ferroptosis. Copper-dependent death occurs by means of direct binding of copper to lipoylated components of the tricarboxylic acid (TCA) cycle. This results in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss, which leads to proteotoxic stress and ultimately cell death (Tsvetkov et al., 2022). Nowadays, cuproptosis has been associated with diseases such as amyotrophic lateral sclerosis (ALS), breast cancer, melanoma, adult neuroblastoma, and prostate cancer.

TargetMol’s Cuproptosis Compound Library is a collection of 411 compounds related to copper-dependent death that can be used to study its mechanism and related diseases.

<span style="font-size: 14px; display: block;font-weight:bold"<Reference:</span<<span style="font-size: 12px;font-family: 'Segoe UI',serif"<Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R. D., Eaton, J. K., Frenkel, E., Kocak, M., Corsello, S. M., Lutsenko, S., Kanarek, N., Santagata, S., & Golub, T. R. (2022). Copper induces cell death by targeting lipoylated TCA cycle proteins. Science (New York, N.Y.), 375(6586), 1254-1261. https://doi.org/10.1126/science.abf0529</span<

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Compound Libraries | TargetMol
Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com
Request Library
Get quote

Product Description

  • 411 active small molecules associated with cuproptosis for high-throughput and high-intensity screening.
  • Targeting Ferredoxin 1 (FDX1), Antioxidant 1 Copper Chaperone (ATOX1), CCS (copper chaperones), mitochondrial respiration, etc.
  • Some compounds are FDA-approved.
  • Detailed instructions, compound structure, target information, description of activity, etc.
  • Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files
Request Library Compound List (L8710)

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..
Hide

Library Composition

Reactive Oxygen Species (160)
Autophagy (104)
Apoptosis (101)
Endogenous Metabolite (58)
BCL (55)
Mitophagy (55)
ROS (52)
Mitochondrial Metabolism (50)
Antibacterial (30)
COX (19)
Ferroptosis (19)
NF-κB (17)
HIV Protease (16)
Antioxidant (13)
PDE (12)
IAP (12)
Antibiotic (12)
Antifungal (12)
Caspase (12)
Influenza Virus (11)
Parasite (11)
HSP (10)
Topoisomerase (8)
TNF (8)
Dehydrogenase (8)
IL Receptor (8)
PKM (8)
NO Synthase (7)
Calcium Channel (7)
PARP (6)
p38 MAPK (6)
PPAR (6)
ATPase (6)
HIF/HIF Prolyl-Hydroxylase (6)
ALK (6)
Estrogen/progestogen Receptor (6)
P450 (6)
Xanthine Oxidase (5)
Akt (5)
PI3K (5)
AMPK (5)
MMP (5)
p53 (5)
GABA Receptor (5)
Virus Protease (4)
E1/E2/E3 Enzyme (4)
HDAC (4)
DNA/RNA Synthesis (4)
c-Met/HGFR (4)
PKC (4)
NOS (4)
NADPH (4)
Potassium Channel (3)
OXPHOS (3)
IκB/IKK (3)
JNK (3)
HSV (3)
Lipoxygenase (3)
Microtubule Associated (3)
Histamine Receptor (3)
mTOR (3)
P-gp (3)
JAK (3)
5-HT Receptor (3)
Gamma-secretase (3)
FLT (3)
Sodium Channel (3)
ERK (3)
Trk receptor (3)
Adrenergic Receptor (3)
VEGFR (3)
Wnt/beta-catenin (3)
Monocarboxylate transporter (2)
Glutathione reductase (2)
AChR (2)
c-Kit (2)
MAO (2)
Chloride channel (2)
CFTR (2)
TLR (2)
Opioid Receptor (2)
Phospholipase (2)
Beta Amyloid (2)
IRE1 (2)
Anti-infection (2)
PDK (2)
PDGFR (2)
Tyrosine Kinases (2)
Cysteine Protease (2)
ROR (2)
STAT (2)
Estrogen Receptor/ERR (2)
Reverse Transcriptase (2)
HBV (2)
HCV Protease (2)
RAAS (2)
SARS-CoV (2)
HMG-CoA Reductase (2)
SGLT (2)
IGF-1R (2)
Interleukin (2)
Dopamine Receptor (2)
Epigenetic Reader Domain (2)
Dynamin (2)
PKA (1)
Src (1)
Retinoid Receptor (1)
UGT (1)
RSV (1)
S6 Kinase (1)
Tyrosinase (1)
RAR/RXR  (1)
TRP/TRPV Channel (1)
STING (1)
Proteasome (1)
Phosphatase (1)
Prostaglandin Receptor (1)
Somatostatin (1)
Sirtuin (1)
Phosphorylase (1)
Thrombin (1)
TGF-beta/Smad (1)
Syk (1)
Platelet aggregation (1)
Immunology/Inflammation related (1)
Nrf2 (1)
cAMP (1)
FAAH (1)
Drug Metabolite (1)
DNA (1)
Discoidin Domain Receptor (DDR) (1)
CRISPR/Cas9 (1)
CDK (1)
CAT (1)
Casein Kinase (1)
Carbonic Anhydrase (1)
CaMK (1)
Free radical scavengers (1)
ATM/ATR (1)
Aromatase (1)
Antiviral (1)
Annexin A (1)
Androgen Receptor (1)
Aminopeptidase (1)
AhR (1)
Adenosine Receptor (1)
ADC Cytotoxin (1)
aconitase (1)
FGFR (1)
FXR (1)
NOD-like Receptor (NLR) (1)
IRAK (1)
NOD (1)
NMDAR (1)
NADPH-oxidase (1)
MyD88 (1)
Monoamine Oxidase (1)
Melatonin Receptor (1)
MEK (1)
Mdm2 (1)
LRRK2 (1)
AChE (1)
Glucocorticoid Receptor (1)
IFNAR (1)
Histone Demethylase (1)
Histone Acetyltransferase (1)
HIF (1)
Hexokinase (1)
Hedgehog/Smoothened (1)
GST (1)
GPR (1)
Glutathione Peroxidase (1)
GluR (1)
YAP (1)

Library Information Sample

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
CORPORATE
About Us Careers Privacy Notice Events & News Terms & Conditions
SUPPORT
Contact Us Worldwide Distributors Quality Control Technical Support
RESOURCE
Product Catalog Product Citations Signaling Pathways Solution Calculators
FOLLOW OUR
Social Network
Newsletter Subscription
Subscribe to receive our lastest product updates and special offers!
Corporate
Support
Resource
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
TargetMol
Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved.