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TargetMol | Compound Library

Cuproptosis Compound Library

Catalog No. L8710

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms (Tsvetkov et al., 2022). The mechanism of cuproptosis (copper-dependent death), is significantly different from other known cell death such as apoptosis, pyroptosis, necrosis and ferroptosis. Copper-dependent death occurs by means of direct binding of copper to lipoylated components of the tricarboxylic acid (TCA) cycle. This results in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss, which leads to proteotoxic stress and ultimately cell death (Tsvetkov et al., 2022). Nowadays, cuproptosis has been associated with diseases such as amyotrophic lateral sclerosis (ALS), breast cancer, melanoma, adult neuroblastoma, and prostate cancer. TargetMol's Cuproptosis Compound Library is a collection of 400 compounds related to copper-dependent death that can be used to study its mechanism and related diseases. Reference:Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R. D., Eaton, J. K., Frenkel, E., Kocak, M., Corsello, S. M., Lutsenko, S., Kanarek, N., Santagata, S., & Golub, T. R. (2022). Copper induces cell death by targeting lipoylated TCA cycle proteins. Science (New York, N.Y.), 375(6586), 1254-1261. https://doi.org/10.1126/science.abf0529

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Catalog No. L8710

Cuproptosis Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • 400 active small molecules associated with cuproptosis for high-throughput and high-intensity screening.
  • Targeting Ferredoxin 1 (FDX1), Antioxidant 1 Copper Chaperone (ATOX1), CCS (copper chaperones), mitochondrial respiration, etc.
  • Some compounds are FDA-approved.
  • Detailed instructions, compound structure, target information, description of activity, etc.
  • Various detection techniques such as NMR, HPLC/LCMS to ensure the correct structure and high purity of the product and reduce false positives.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Reactive Oxygen Species
Autophagy
Apoptosis
Mitochondrial Metabolism
Bcl-2 Family
Mitophagy
Endogenous Metabolite
ROS
Antibacterial
COX
HIV Protease
Ferroptosis
NF-κB
Antioxidant
PDE
Antifungal
Caspase
IAP
Antibiotic
Parasite
HSP
Dehydrogenase
Topoisomerase
Influenza Virus
ROS Kinase
p38 MAPK
IL Receptor
HIF/HIF Prolyl-Hydroxylase
PKM
ATPase
Estrogen/progestogen Receptor
PARP
Calcium Channel
Cytochromes P450
ALK
HDAC
TNF
NO Synthase
PPAR
Xanthine Oxidase
Akt
Nrf2
AMPK
GABA Receptor
p53
c-Met/HGFR
PI3K
NADPH
Virus Protease
Bcl-6
MMP
NOS
Histamine Receptor
JNK
Wnt/beta-catenin
VEGFR
PKC
E1/E2/E3 Enzyme
Gamma-secretase
JAK
HSV
Lipoxygenase
mTOR
DNA/RNA Synthesis
P-gp
Trk receptor
IκB/IKK
5-HT Receptor
Potassium Channel
FLT
Sodium Channel
Microtubule Associated
Mdm2
Chloride channel
CAT
Monocarboxylate transporter
ROR
HCV Protease
Dynamin
RAAS
Estrogen Receptor/ERR
HBV
Tyrosine Kinases
Cysteine Protease
ERK
Adrenergic Receptor
MAO
IRE1
Opioid Receptor
PDGFR
Epigenetic Reader Domain
IGF-1R
OXPHOS
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TLR
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AChR
c-Kit
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CFTR
GPCR
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Ligands for Target Protein for PROTAC
YAP
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IFNAR
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CaSR
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