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Penfluridol

Name: Penfluridol
Brand: TargetMol
SKU: T1105
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1105Cas No. 26864-56-2

Alias TLP-607, R-16341

Penfluridol (TLP-607) is a highly potent antipsychotic.

Penfluridol

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Purity: 99.87%

Catalog No. T1105Alias TLP-607, R-16341Cas No. 26864-56-2

Penfluridol (TLP-607) is a highly potent antipsychotic.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$60	In Stock	In Stock
500 mg	$123	-	In Stock
1 g	$188	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Penfluridol (TLP-607) is a highly potent antipsychotic.
Targets&IC50	Dopamine receptor:1.6 μM(Ki)
In vivo	Penfluridol inhibits the binding of dopamine to its receptors with a Ki value of 1.6 μM. At a concentration of 10 μM, Penfluridol suppresses the contractile response of isolated rabbit thoracic aortic rings to NE and KCl, as well as the calcium influx stimulated by NE or KCl. Additionally, Penfluridol selectively inhibits the binding of [3H]Nitrendipine to rat cerebral cortex membranes and competitively antagonizes potassium-induced, calcium-dependent contractions in the rat vas deferens.
Synonyms	TLP-607, R-16341

Chemical Properties

Molecular Weight	523.97
Formula	C₂₈H₂₇ClF₅NO
Cas No.	26864-56-2
Smiles	OC1(C2=CC(C(F)(F)F)=C(Cl)C=C2)CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC1
Relative Density.	1.2425 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (177.49 mM), Sonication is recommended.

DMSO: 250 mg/mL (477.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9085 mL	9.5425 mL	19.0851 mL	95.4253 mL
5 mM	0.3817 mL	1.9085 mL	3.8170 mL	19.0851 mL
10 mM	0.1909 mL	0.9543 mL	1.9085 mL	9.5425 mL
20 mM	0.0954 mL	0.4771 mL	0.9543 mL	4.7713 mL
50 mM	0.0382 mL	0.1909 mL	0.3817 mL	1.9085 mL
100 mM	0.0191 mL	0.0954 mL	0.1909 mL	0.9543 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc