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TABERSONINE HYDROCHLORIDE

Name: TABERSONINE HYDROCHLORIDE
Brand: TargetMol
SKU: T5810
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5810Cas No. 29479-00-3

TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.

TABERSONINE HYDROCHLORIDE

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Purity: 98.17%

Catalog No. T5810Cas No. 29479-00-3

TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$37	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$91	In Stock	In Stock
50 mg	$137	In Stock	In Stock
100 mg	$198	In Stock	In Stock
500 mg	$436	-	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.17%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.

In vivo

TABERSONINE HYDROCHLORIDE is an indole alkaloid mainly isolated from Catharanthus roseus, and a potential drug candidate for treatment of cancer and Alzheimer's disease (AD), however, its anti-inflammatory effect has not been revealed.TABERSONINE HYDROCHLORIDE ameliorated lipopolysaccharides (LPS)-induced ALI in vivo and inhibited LPS-mediated macrophage activation in vitro. By using murine ALI model, we found that TABERSONINE HYDROCHLORIDE significantly attenuated LPS-induced pathological injury in the lung. TABERSONINE HYDROCHLORIDE also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-α, IL-6 and IL-1β. Furthermore, TABERSONINE HYDROCHLORIDE inhibited LPS-induced the production of pro-inflammatory mediators such as iNOS, NO and cytokines by suppressing NF-κB and p38 MAPK/MK2 signaling cascades. TABERSONINE HYDROCHLORIDE HYDROCHLORIDE reduced the K63-linked polyubiquitination of TRAF6. Taken together,TABERSONINE HYDROCHLORIDE has anti-inflammatory activities in vitro and in vivo, and is a potential therapeutic candidate for the treatment of ALI/ARDS[1].

Chemical Properties

Molecular Weight	372.89
Formula	C₂₁H₂₅ClN₂O₂
Cas No.	29479-00-3
Smiles	Cl.[H][C@@]12N3CC[C@]11C(Nc4ccccc14)=C(C[C@]2(CC)C=CC3)C(=O)OC
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 3 mg/mL (8.05 mM), Sonication is recommended.

DMSO: 50 mg/mL (134.09 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6818 mL	13.4088 mL	26.8176 mL	134.0878 mL
5 mM	0.5364 mL	2.6818 mL	5.3635 mL	26.8176 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2682 mL	1.3409 mL	2.6818 mL	13.4088 mL
20 mM	0.1341 mL	0.6704 mL	1.3409 mL	6.7044 mL
50 mM	0.0536 mL	0.2682 mL	0.5364 mL	2.6818 mL
100 mM	0.0268 mL	0.1341 mL	0.2682 mL	1.3409 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc