Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effectively suppresses the proliferation of various cancer cell lines, including MDA-MB-231, MCF-7, A549, and HCT-116. Additionally, it triggers cell cycle arrest and apoptosis in HCT-116 cells and impedes their migration [1].
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Description | HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effectively suppresses the proliferation of various cancer cell lines, including MDA-MB-231, MCF-7, A549, and HCT-116. Additionally, it triggers cell cycle arrest and apoptosis in HCT-116 cells and impedes their migration [1]. |
Molecular Weight | 626.11 |
Formula | C33H32ClN7O4 |
CAS No. | 2987905-95-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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HDAC1/CDK7-IN-1 2987905-95-1 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC inhibitor inhibit