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MCLA hydrochloride

Name: MCLA hydrochloride
Brand: TargetMol
SKU: T19024
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Synonyms:

Catalog No. T19024 Copy Product Info

Purity: 99.96%

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MCLA hydrochloride is a monoclonal antibody that binds EGFR and LGR5 with Kd values of 0.22 nM and 0.86 nM, respectively. MCLA hydrochloride induces EGFR signaling blockade and receptor degradation in LGR5-positive cancer cells. MCLA hydrochloride is utilized in oncology research involving solid tumors, including head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC), and serves as a molecular tool for investigating EGFR- and LGR5-associated signaling pathways and tumor biology.

Cas No. 128322-44-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$45	-	In Stock
5 mg	$106	-	In Stock
10 mg	$189	-	In Stock
25 mg	$413	-	In Stock
50 mg	$589	-	In Stock
100 mg	$855	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.96%

Appearance:Solid

Color:Green

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COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

The non-specific luminescence remains stable for 10 minutes post-addition of MCLA hydrochloride and is not significantly affected by SOD. The MCLA method is 4.5 times more sensitive than the CLA method.

Chemical Properties

Molecular Weight	291.73
Formula	C₁₄H₁₄ClN₃O₂
Cas No.	128322-44-1
Smiles	Cl.O=C1C(=NC2=CNC(=CN21)C=3C=CC(OC)=CC3)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (27.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4278 mL	17.1391 mL	34.2783 mL	171.3914 mL
5 mM	0.6856 mL	3.4278 mL	6.8557 mL	34.2783 mL
10 mM	0.3428 mL	1.7139 mL	3.4278 mL	17.1391 mL
20 mM	0.1714 mL	0.8570 mL	1.7139 mL	8.5696 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc