Ligand for E3 Ligase

A required PROTAC component is a ligand binding to an E3 ubiquitin ligase, which is then joined to another ligand binding to a protein to be degraded via the ubiquitin–proteasome system. The advent of nonpeptidic small-molecule E3 ligase ligands, notably for von Hippel–Lindau (VHL) and cereblon (CRBN), revolutionized the field and ushered in the design of drug-like PROTACs with potent and selective degradation activity.

Cat. No.	Product name	CAS No.	Purity
T18661	(S,R,S)-AHPC-C10-NH2 dihydrochloride	2341796-75-4	98%
T18661	(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and a l...
T18822	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride	2245697-85-0	98%
T18822	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker...
T17913	(S,R,S)-AHPC-PEG2-N3	2010159-45-0	98%
T17913	(S,R,S)-AHPC-PEG2-N3 (VHL Ligand-Linker Conjugates 6) is a synthesized E3 ligase ligand-linker conjugate containing a (S,R,S)-AHPC based VHL ligand and 2 unit PE...
T9360	CRBN ligand-9	55003-81-1	99.88%
T9360	CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN.
T7752	(S,R,S)-AHPC-Me	1948273-02-6	99.86%
T7752	(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R...
T5334	VL285	1448188-57-5	99.85%
T5334	VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.
T7758	Thalidomide-O-amido-PEG3-C2-NH2 TFA	1957236-21-3	99.82%
T7758	Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-PEG3-C2-N...
T18066	Lenalidomide-OH	1416990-08-3	99.77%
T18066	Lenalidomide-OH is a ligand of cereblon (CRBN), serving as an analog to Lenalidomide for E3 ubiquitin ligase. It is utilized in the recruitment of CRBN protein. ...
T29106	VH032	1448188-62-2	99.72%
T29106	VH032 commonly used as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs...
T7761	Pomalidomide-C2-NH2 hydrochloride	2305369-00-8	99.66%
T7761	Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Pomalidomide-C2-NH2 hydrochloride incorporates the Pomalidomide based cereb...
T7763	Thalidomide-4-OH	5054-59-1	99.59%
T7763	Thalidomide-4-OH (E3 ligase Ligand 2) (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon li...
T1642	Lenalidomide	191732-72-6	99.5%
T1642	Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
T7756	Pomalidomide-PEG4-Ph-NH2	1818885-63-0	99.49%
T7756	Pomalidomide-PEG4-Ph-NH2 is a synthetic E3 ligase ligand-linker conjugate combining a Pomalidomide-based cereblon ligand and a 4-unit PEG linker.
T10765	Eragidomide	1860875-51-9	99.41%
T10765	Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of ...
T40028	(S,R,S)-AHPC	2055344-67-5	99.40%
T40028	(S,R,S)-AHPC is a VHL ligand that used in the recruitment of the VHL protein.
T18787	TD-165	2305936-56-3	99.24%
T18787	TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
T8824	CRBN modulator-1	2407829-65-4	99.24%
T8824	CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
T7755	Thalidomide 4-fluoride	835616-60-9	99.12%
T7755	Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment o...
T9117	BSJ-4-116	2519823-34-6	99.09%
T9117	BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcript...
T14893	CC-885	1010100-07-8	99.08%
T14893	CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity.