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Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945)
😃Good
Catalog No. TMAY-01628
Alias Zn-SMase, sphingomyelin phosphodiesterase 1, A-SMase, aSMase, ASM
Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) is a Mouse antibody targeting Acid sphingomyelinase/SMPD1. Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) can be used in ELISA.
Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945)
Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945)
😃Good
Catalog No. TMAY-01628Alias Zn-SMase, sphingomyelin phosphodiesterase 1, A-SMase, aSMase, ASM
Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) is a Mouse antibody targeting Acid sphingomyelinase/SMPD1. Anti-Acid sphingomyelinase/SMPD1 Antibody (9W945) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | Zn-SMase, sphingomyelin phosphodiesterase 1, A-SMase, aSMase, ASM |
| Ig Type | Mouse IgG1 |
| Clone | 9W945 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SMPD1 (rh SMPD1; TMPY-01159; NP_000534.3; Met1-Pro628). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monomeric lysosomal enzyme that converts sphingomyelin (a plasma membrane lipid ) into ceramide through the removal of phosphorylcholine. This generates second messenger components that participate in signal transduction. Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPA) and type B (NPB), also known as Niemann-Pick disease classical infantile form and Niemann-Pick disease visceral form. Niemann-Pick disease is a clinically and genetically heterogeneous recessive disorder. NPB has little if any neurologic involvement and patients may survive into adulthood. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human SMPD1 Protein (TMPY-01159) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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