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Anti-F8/Factor VIII Antibody
🥰Excellent
Catalog No. T9901A-1275
Anti-F8/Factor VIII Antibody is a CHO-expressed humanized monoclonal antibody. This product binds specifically to Coagulation Factor VIII (F8) with high affinity, blocking its cofactor function in the coagulation cascade. Featuring a huIgG4 heavy chain and huκ light chain, it serves as an important pharmacological tool for researching Hemophilia A, inhibitor formation, and the regulation of blood coagulation.
Anti-F8/Factor VIII Antibody
Anti-F8/Factor VIII Antibody
🥰Excellent
Catalog No. T9901A-1275
Anti-F8/Factor VIII Antibody is a CHO-expressed humanized monoclonal antibody. This product binds specifically to Coagulation Factor VIII (F8) with high affinity, blocking its cofactor function in the coagulation cascade. Featuring a huIgG4 heavy chain and huκ light chain, it serves as an important pharmacological tool for researching Hemophilia A, inhibitor formation, and the regulation of blood coagulation.
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| Description | Anti-F8/Factor VIII Antibody is a CHO-expressed humanized monoclonal antibody. This product binds specifically to Coagulation Factor VIII (F8) with high affinity, blocking its cofactor function in the coagulation cascade. Featuring a huIgG4 heavy chain and huκ light chain, it serves as an important pharmacological tool for researching Hemophilia A, inhibitor formation, and the regulation of blood coagulation. |
| In vitro | In biochemical and neutralization assays,Anti-F8/Factor VIII Antibody exhibits high binding specificity for the heavy and/or light chains of human Factor VIII, effectively neutralizing its procoagulant activity in chromogenic or clot-based assays in a concentration-dependent manner [1]. |
| In vivo | In pharmacological studies using hemophilia A mouse models or primates, systemic administration of Anti-F8/Factor VIII Antibody has been utilized to evaluate the clearance kinetics of F8 and the induction of F8 inhibitors; results demonstrate that the antibody can effectively modulate F8 plasma levels and facilitate the study of immune-mediated inactivation of coagulation factors [1][2]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | F8/FactorVIII |
| Isotype | IgG1 |
| Storage | store at low temperature | Lyophilized powder: -20~-80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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