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TAK-779

Name: TAK-779
Brand: TargetMol
SKU: T7499
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7499Cas No. 229005-80-5

Alias Takeda 779

TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).

TAK-779

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Purity: 99.21%

Catalog No. T7499Alias Takeda 779Cas No. 229005-80-5

TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$253	In Stock	In Stock
50 mg	$428	In Stock	In Stock
100 mg	$639	-	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.21%

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
Targets&IC50	R5 HIV-1 (KK):20.8 nM (EC90, in PBMCs), MIP-1α-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (CTV):3.5 nM (EC50 , in PBMCs), RANTES-CCR5:1.4 nM (in CHO/CCR5 cells), R5 HIV-1 (Ba-L):5.7 nM (EC90, in MAGI-CCR5 cells), MCP-1-CCR2b:27 nM (in CHO/CCR5 cells), CXCR3 (mouse):369 nM (in PBMCs), R5 HIV-1 (Ba-L):1.2 nM (EC50, in MAGI-CCR5 cells), R5 HIV-1 (Ba-L):12.8 nM (EC90, in PBMCs), R5 HIV-1 (CTV):27 nM (EC90, in PBMCs), R5 HIV-1 (Ba-L):3.7 nM (EC50, in PBMCs), R5 HIV-1 (HHA):7.5 nM (EC90, in PBMCs), MIP-1β-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (HHA):3.2 nM (EC50 , in PBMCs), R5 HIV-1 (KK):1.6 nM (EC50, in PBMCs)
In vitro	TAK-779 (250 mg/animal per day) inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in bronchoalveolar lavage fluid (BALF), in a mouse model of asthma[1].
In vivo	TAK-779 increases intestinal allograft survival in a rat model of small intestine transplantation when administered at a dose of 10 mg/kg per day[2].
Synonyms	Takeda 779

Chemical Properties

Molecular Weight	531.13
Formula	C₃₃H₃₉ClN₂O₂
Cas No.	229005-80-5
Smiles	[Cl-].Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 16.66 mg/mL (31.37 mM), Sonication is recommended.

DMSO: 25 mg/mL (47.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8828 mL	9.4139 mL	18.8278 mL	94.1389 mL
5 mM	0.3766 mL	1.8828 mL	3.7656 mL	18.8278 mL
10 mM	0.1883 mL	0.9414 mL	1.8828 mL	9.4139 mL
20 mM	0.0941 mL	0.4707 mL	0.9414 mL	4.7069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc