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TAK-779

Name: TAK-779
Brand: TargetMol
SKU: T7499
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7499Cas No. 229005-80-5

Alias Takeda 779

TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).

TAK-779

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Purity: 99.21%

Catalog No. T7499Alias Takeda 779Cas No. 229005-80-5

TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$139	In Stock	In Stock
25 mg	$253	In Stock	In Stock
50 mg	$428	In Stock	In Stock
100 mg	$639	-	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.21%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
Targets&IC50	RANTES-CCR5:1.4 nM (in CHO/CCR5 cells), CXCR3 (mouse):369 nM (in PBMCs), R5 HIV-1 (HHA):7.5 nM (EC90, in PBMCs), R5 HIV-1 (HHA):3.2 nM (EC50 , in PBMCs), R5 HIV-1 (KK):1.6 nM (EC50, in PBMCs), R5 HIV-1 (KK):20.8 nM (EC90, in PBMCs), MCP-1-CCR2b:27 nM (in CHO/CCR5 cells), MIP-1β-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (Ba-L):5.7 nM (EC90, in MAGI-CCR5 cells), R5 HIV-1 (Ba-L):12.8 nM (EC90, in PBMCs), R5 HIV-1 (Ba-L):1.2 nM (EC50, in MAGI-CCR5 cells), R5 HIV-1 (Ba-L):3.7 nM (EC50, in PBMCs), MIP-1α-CCR5:1 nM (in CHO/CCR5 cells), R5 HIV-1 (CTV):3.5 nM (EC50 , in PBMCs), R5 HIV-1 (CTV):27 nM (EC90, in PBMCs)
In vitro	TAK-779 (250 mg/animal per day) inhibits ovalbumin-induced increases in CCR5, CXCR3, IFN-γ, and TNF-α expression in mouse lung, as well as the number of total cells, lymphocytes, and eosinophils in bronchoalveolar lavage fluid (BALF), in a mouse model of asthma[1].
In vivo	TAK-779 increases intestinal allograft survival in a rat model of small intestine transplantation when administered at a dose of 10 mg/kg per day[2].
Synonyms	Takeda 779

Chemical Properties

Molecular Weight	531.13
Formula	C₃₃H₃₉ClN₂O₂
Cas No.	229005-80-5
Smiles	[Cl-].Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 16.66 mg/mL (31.37 mM), Sonication is recommended.

DMSO: 25 mg/mL (47.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8828 mL	9.4139 mL	18.8278 mL	94.1389 mL
5 mM	0.3766 mL	1.8828 mL	3.7656 mL	18.8278 mL
10 mM	0.1883 mL	0.9414 mL	1.8828 mL	9.4139 mL
20 mM	0.0941 mL	0.4707 mL	0.9414 mL	4.7069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc