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CK-666

🥰Excellent
Catalog No. T10826Cas No. 442633-00-3

CK-666 is a cell-permeable inhibitor of the actin-related protein Arp2/3 complex, binding to and stabilizing its inactive state, thereby preventing the movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) configuration.

CK-666

CK-666

🥰Excellent
Purity: 99.93%
Catalog No. T10826Cas No. 442633-00-3
CK-666 is a cell-permeable inhibitor of the actin-related protein Arp2/3 complex, binding to and stabilizing its inactive state, thereby preventing the movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) configuration.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$34In StockIn Stock
5 mg$79In StockIn Stock
10 mg$143In StockIn Stock
25 mg$296In StockIn Stock
50 mg$573In StockIn Stock
100 mg$795In StockIn Stock
200 mg$995-In Stock
1 mL x 10 mM (in DMSO)$87In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.93%
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Product Introduction

Bioactivity
Description
CK-666 is a cell-permeable inhibitor of the actin-related protein Arp2/3 complex, binding to and stabilizing its inactive state, thereby preventing the movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) configuration.
Chemical Properties
Molecular Weight296.34
FormulaC18H17FN2O
Cas No.442633-00-3
SmilesCc1[nH]c2ccccc2c1CCNC(=O)c1ccccc1F
Relative Density.1.235 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 125 mg/mL (421.81 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (33.75 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3745 mL16.8725 mL33.7450 mL168.7251 mL
5 mM0.6749 mL3.3745 mL6.7490 mL33.7450 mL
10 mM0.3375 mL1.6873 mL3.3745 mL16.8725 mL
20 mM0.1687 mL0.8436 mL1.6873 mL8.4363 mL
50 mM0.0675 mL0.3375 mL0.6749 mL3.3745 mL
100 mM0.0337 mL0.1687 mL0.3375 mL1.6873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

trabecularstateMicrotubuleAssociatedMicrotubule AssociatedmeshworkInhibitorinhibitHuman immunodeficiency virusHIVProteaseHIV ProteaseHIVeffectorCK-666CK666CK 666Arp2/3 complexArp2/3 ComplexallostericactiveActin-related protein 2/3 complex
Related Tags: buy CK-666 | purchase CK-666 | CK-666 cost | order CK-666 | CK-666 chemical structure | CK-666 formula | CK-666 molecular weight
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