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L6H21

Name: L6H21
Brand: TargetMol
SKU: T69626
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T69626Cas No. 24533-47-9

Alias L6H-21

L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.

L6H21

🥰Excellent

Purity: 99.26%

Catalog No. T69626Alias L6H-21Cas No. 24533-47-9

L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$108	In Stock
25 mg	$239	In Stock
50 mg	$388	In Stock
100 mg	$629	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.26%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.
Targets&IC50	IL-6:8.59 μM
In vitro	The cells were exposed to ethanol (EtOH; 100 mmol/l) for 48 hours prior to the treatment with LPS at 500 ng/ml for 6 hours. L6H21 was administered (10 or 20 μmol/l) 2 hours before EtOH treatment. L6H21 protects against oxidative stress and apoptosis induced by EtOH and/or LPS in RAW264.7 cells. [1]
In vivo	A group of mice was treated with L6H21 via oral gavage at a dose of 10 mg/kg/d on the same day as the start of alcohol feeding. L6H21 treatment significantly decreased inflammation in liver tissue induced by EtOH + LPS. LPS aggravated EtOH-induced hepatic steatosis and liver injury, which was improved with L6H21 pretreatment. L6H21 treatment plays an important role in the inhibition of EtOH + LPS-induced inflammasome activation in the liver. [1]
Synonyms	L6H-21

Chemical Properties

Molecular Weight	298.33
Formula	C₁₈H₁₈O₄
Cas No.	24533-47-9
Smiles	O(C)C1=C(/C=C/C(=O)C2=CC=C(OC)C=C2)C=CC=C1OC
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (268.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3520 mL	16.7600 mL	33.5199 mL	167.5996 mL
5 mM	0.6704 mL	3.3520 mL	6.7040 mL	33.5199 mL
10 mM	0.3352 mL	1.6760 mL	3.3520 mL	16.7600 mL
20 mM	0.1676 mL	0.8380 mL	1.6760 mL	8.3800 mL
50 mM	0.0670 mL	0.3352 mL	0.6704 mL	3.3520 mL
100 mM	0.0335 mL	0.1676 mL	0.3352 mL	1.6760 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc