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L6H21

Name: L6H21
Brand: TargetMol
SKU: T69626
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69626Cas No. 24533-47-9

Alias L6H-21

L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.

L6H21

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Purity: 99.26%

Catalog No. T69626Alias L6H-21Cas No. 24533-47-9

L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$108	-	In Stock
25 mg	$239	-	In Stock
50 mg	$388	-	In Stock
100 mg	$629	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.26%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.
Targets&IC50	IL-6:8.59 μM
In vitro	The cells were exposed to ethanol (EtOH; 100 mmol/l) for 48 hours prior to the treatment with LPS at 500 ng/ml for 6 hours. L6H21 was administered (10 or 20 μmol/l) 2 hours before EtOH treatment. L6H21 protects against oxidative stress and apoptosis induced by EtOH and/or LPS in RAW264.7 cells. [1]
In vivo	A group of mice was treated with L6H21 via oral gavage at a dose of 10 mg/kg/d on the same day as the start of alcohol feeding. L6H21 treatment significantly decreased inflammation in liver tissue induced by EtOH + LPS. LPS aggravated EtOH-induced hepatic steatosis and liver injury, which was improved with L6H21 pretreatment. L6H21 treatment plays an important role in the inhibition of EtOH + LPS-induced inflammasome activation in the liver. [1]
Synonyms	L6H-21

Chemical Properties

Molecular Weight	298.33
Formula	C₁₈H₁₈O₄
Cas No.	24533-47-9
Smiles	O(C)C1=C(/C=C/C(=O)C2=CC=C(OC)C=C2)C=CC=C1OC

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (268.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3520 mL	16.7600 mL	33.5199 mL	167.5996 mL
5 mM	0.6704 mL	3.3520 mL	6.7040 mL	33.5199 mL
10 mM	0.3352 mL	1.6760 mL	3.3520 mL	16.7600 mL
20 mM	0.1676 mL	0.8380 mL	1.6760 mL	8.3800 mL
50 mM	0.0670 mL	0.3352 mL	0.6704 mL	3.3520 mL
100 mM	0.0335 mL	0.1676 mL	0.3352 mL	1.6760 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc