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Salsalate

Name: Salsalate
Brand: TargetMol
SKU: T0498
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0498Cas No. 552-94-3

Alias Sasapyrine, Salicylsalicylic acid, NSC-49171, Disalicylic acid

Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.

Salsalate

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Purity: 99.76%

Catalog No. T0498Alias Sasapyrine, Salicylsalicylic acid, NSC-49171, Disalicylic acidCas No. 552-94-3

Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$38	-	In Stock
10 g	$56	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Salsalate AI Summary

Salsalate exhibits a range of bioactivities and toxicological profiles. It shows beta-blocking activity based on stepwise linear discriminate analysis but is considered inactive with an activity value of -6.7. The compound acts as an inhibitor in various assays, including HSD17B4 (25,118.9 nM), JMJD2E (28,183.8 nM), ALDH1A1 (35,481.3 nM), HPGD (17,782.8 nM), the S16 Schwann cell PMP22 firefly luciferase assay (10,181.5 nM), and also blocks Ebola Virus entry with AC50 values from 0.631 uM to 8.913 uM. It exhibits moderate hepatotoxicity with elevation in ALT, AST, and alkaline phosphatase levels, as well as cytolytic liver toxicity, but shows no severe chronic liver diseases or tumors. Additionally, it weakly inhibits human BSEP activity (IC50 > 1,000,000.0 nM) and induces drug-induced liver injury with a severity class index of 3.0. Salsalate has antiviral activity against SARS-CoV-2, showing inhibition of virus-induced cytotoxicity in Caco-2 and VERO-6 cells, although with limited potency (e.g., inhibition rate of 20.56% at 10 uM in Caco-2 cells and -0.1% in VERO-6 cells). It inhibits the SARS-CoV-2 3CL-Pro protease with percentages of 23.15% and 2.742% at 20µM. Additionally, the compound demonstrates 43.16% inhibition of HDAC6 activity in one enzymatic assay, but a -6.07% in another. Overall, it shows limited bioactivity in various assays, often with AC50 values above 30,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.
Synonyms	Sasapyrine, Salicylsalicylic acid, NSC-49171, Disalicylic acid

Chemical Properties

Molecular Weight	258.23
Formula	C₁₄H₁₀O₅
Cas No.	552-94-3
Smiles	OC(=O)C1=CC=CC=C1OC(=O)C1=C(O)C=CC=C1
Relative Density.	1.404g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 49 mg/mL (189.75 mM), Sonication is recommended.

DMSO: 55 mg/mL (212.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.75 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8725 mL	19.3626 mL	38.7252 mL	193.6258 mL
5 mM	0.7745 mL	3.8725 mL	7.7450 mL	38.7252 mL
10 mM	0.3873 mL	1.9363 mL	3.8725 mL	19.3626 mL
20 mM	0.1936 mL	0.9681 mL	1.9363 mL	9.6813 mL
50 mM	0.0775 mL	0.3873 mL	0.7745 mL	3.8725 mL
100 mM	0.0387 mL	0.1936 mL	0.3873 mL	1.9363 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc