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Revaprazan hydrochloride

Name: Revaprazan hydrochloride
Brand: TargetMol
SKU: T2405
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2405Cas No. 178307-42-1

Alias YH1885

Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.

Revaprazan hydrochloride

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Purity: 99.91%

Catalog No. T2405Alias YH1885Cas No. 178307-42-1

Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$74	In Stock	In Stock
50 mg	$115	In Stock	In Stock
100 mg	$181	In Stock	In Stock
500 mg	$448	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:White

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Product Introduction

Revaprazan hydrochloride AI Summary

Revaprazan hydrochloride inhibits the H^+/K^+/ATPase enzyme, with an IC50 value of 350.0 nM. It has a logP(lung) value of 1.34, indicating its affinity or distribution within lung tissues compared to plasma in rats. Additionally, Revaprazan hydrochloride exhibits antiviral activity; it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with a high inhibition rate of 90.92% at a concentration of 10 μM after 48 hours. In VERO-6 cells, the compound shows 5.47% inhibition of SARS-CoV-2 induced cytotoxicity under similar conditions. Furthermore, it inhibits the SARS-CoV-2 3CL-Pro protease by 18.63% at a concentration of 20 μM through a FRET response from a peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.
Synonyms	YH1885

Chemical Properties

Molecular Weight	398.9
Formula	C₂₂H₂₄ClFN₄
Cas No.	178307-42-1
Smiles	Cl.CC1N(CCc2ccccc12)c1nc(Nc2ccc(F)cc2)nc(C)c1C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 3.99 mg/mL (10 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5069 mL	12.5345 mL	25.0689 mL	125.3447 mL
5 mM	0.5014 mL	2.5069 mL	5.0138 mL	25.0689 mL
10 mM	0.2507 mL	1.2534 mL	2.5069 mL	12.5345 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc