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HCV-IN-30

Name: HCV-IN-30
Brand: TargetMol
SKU: T11541
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11541Cas No. 1007882-23-6

HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).

HCV-IN-30

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Purity: 99.6%

Catalog No. T11541Cas No. 1007882-23-6

HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	-	In Stock
100 mg	$56	-	In Stock
500 mg	$148	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.6%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

HCV-IN-30 AI Summary

HCV-IN-30 exhibits antiviral activity against Bovine viral diarrhea virus, as well as Hepatitis C virus genotypes 1a and 1b in human HuH7 cells. It also demonstrates cytotoxicity against HCV genotype 1b-infected human HuH7 cells. The compound's potency varies across different assays, with EC50 values ranging from 102.0 nM to 2760.0 nM, and a CC50 value of 9630.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).

Chemical Properties

Molecular Weight	624.77
Formula	C₃₆H₄₄N₆O₄
Cas No.	1007882-23-6
Smiles	CC(C)(C)OC(=O)N1CCC[C@H]1c1nc(c[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1c[nH]c(n1)[C@@H]1CCCN1C(=O)OC(C)(C)C
Relative Density.	1.220 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (36.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6006 mL	8.0029 mL	16.0059 mL	80.0295 mL
5 mM	0.3201 mL	1.6006 mL	3.2012 mL	16.0059 mL
10 mM	0.1601 mL	0.8003 mL	1.6006 mL	8.0029 mL
20 mM	0.0800 mL	0.4001 mL	0.8003 mL	4.0015 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc