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Anti-IL-1R1 Antibody (3D114)
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Catalog No. TMAY-03914
Alias interleukin 1 receptor, type I
Anti-IL-1R1 Antibody (3D114) is a Mouse antibody targeting IL-1R1. Anti-IL-1R1 Antibody (3D114) can be used in ELISA.
Anti-IL-1R1 Antibody (3D114)
Anti-IL-1R1 Antibody (3D114)
😃Good
Catalog No. TMAY-03914Alias interleukin 1 receptor, type I
Anti-IL-1R1 Antibody (3D114) is a Mouse antibody targeting IL-1R1. Anti-IL-1R1 Antibody (3D114) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Cynomolgus |
| Alias | interleukin 1 receptor, type I |
| Ig Type | Mouse IgG1 |
| Clone | 3D114 |
| Reactivity | Cynomolgus |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Cynomolgus IL-1R1 / CD121a (TMPY-03744; EHH61701.1; Met1-Thr332). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Cynomolgus IL-1R1 / CD121a protein (TMPY-03744) |
| Antigen Species | Cynomolgus |
| Biology Area | Neuroinflammation |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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