Anti-Phospho-TBK1 (Ser172) Antibody (9M623) is a Rabbit antibody targeting Phospho-TBK1 (Ser172). Anti-Phospho-TBK1 (Ser172) Antibody (9M623) can be used in WB.

IgG

9M623

Human

WB: 1:500-2000

Monoclonal

A synthesized peptide: human TBK1 around the phosphorylation site of S172

Human

TBK1

Serine/threonine-protein kinase TBK1

Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.